Association between platelet to high-density lipoprotein cholesterol ratio (PHR) and hypertension: evidence from NHANES 2005-2018.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2024-10-26 DOI:10.1186/s12944-024-02342-3

Jia Chen, Boyu Wang, Changxing Liu, Chengjia Li, Tianwei Meng, Jiameng Wang, Qingnan Liu, Zhiping Liu, Yabin Zhou

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引用次数: 0

Abstract

Background: The Platelet to High-Density Lipoprotein cholesterol Ratio (PHR) is a novel indicator of inflammatory response and metabolic disorders, linked to various chronic diseases. This study aims to investigate the relationship between PHR and hypertension.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES), collected across seven consecutive cycles from 2005 to 2018, were analyzed. The dataset included participants' hypertension status as reported by a doctor, their use of antihypertensive medications, and the average of three blood pressure measurements to identify hypertensive adults, along with complete information for PHR calculation. PHR was calculated based on Platelet (PLT) count and High-Density Lipoprotein cholesterol (HDL-C) using the following formula: PHR = [PLT (1000 cells/µL) / HDL-C (mmol/L)]. A multivariable logistic regression model was employed to assess the association between PHR and hypertension, and subgroup analyses were conducted to explore potential influencing factors. Additionally, Restricted Cubic Spline (RCS) curves were applied for threshold effect analysis to describe nonlinear relationships.

Results: Higher PHR was associated with an increased prevalence of hypertension. After adjusting for various covariates, including race, education level, Family Poverty Income Ratio (PIR), smoking, alcohol consumption, sleep disturbances, waist circumference, diabetes, coronary heart disease, angina, heart attack, and stroke, the results remained significant (OR = 1.36; 95% CI, 1.32, 1.41, P < 0.001). Participants with the highest PHR levels had a 104% higher risk of hypertension compared to those with the lowest PHR levels (OR = 2.04; 95% CI, 1.89, 2.21, P < 0.001).

Conclusion: Elevated PHR levels are strongly associated with an increased risk of hypertension. Specifically, when PHR is below 280, the risk of hypertension increases in proportion to PHR. This suggests that regular monitoring of PHR may help identify patients at risk of hypertension early, allowing for timely interventions to slow disease progression. Larger cohort studies are necessary to confirm these findings.

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血小板与高密度脂蛋白胆固醇比值 (PHR) 与高血压之间的关系：2005-2018 年 NHANES 的证据。

背景：血小板与高密度脂蛋白胆固醇比（PHR血小板与高密度脂蛋白胆固醇比值（PHR）是炎症反应和代谢紊乱的新指标，与各种慢性疾病相关。本研究旨在调查 PHR 与高血压之间的关系：研究分析了从 2005 年到 2018 年连续七个周期收集的美国国家健康与营养调查（NHANES）数据。数据集包括由医生报告的参与者的高血压状态、使用降压药的情况、三次血压测量的平均值，以确定高血压成人，以及用于计算PHR的完整信息。PHR 根据血小板 (PLT) 计数和高密度脂蛋白胆固醇 (HDL-C) 计算，计算公式如下：PHR = [PLT (1000 cells/µL) / HDL-C (mmol/L)]。采用多变量逻辑回归模型评估 PHR 与高血压之间的关系，并进行亚组分析以探索潜在的影响因素。此外，还采用了限制立方样条曲线（RCS）进行阈值效应分析，以描述非线性关系：结果：PHR 越高，高血压患病率越高。在对种族、教育水平、家庭贫困收入比（PIR）、吸烟、饮酒、睡眠障碍、腰围、糖尿病、冠心病、心绞痛、心脏病发作和中风等各种协变量进行调整后，结果仍然显著（OR = 1.36; 95% CI, 1.32, 1.41, P 结论：PHR 水平升高与高血压患病率增加密切相关：PHR 水平升高与高血压风险增加密切相关。具体来说，当 PHR 低于 280 时，高血压的风险与 PHR 成比例增加。这表明，定期监测 PHR 有助于及早发现有高血压风险的患者，从而及时采取干预措施，减缓疾病的发展。有必要进行更大规模的队列研究来证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.