A retrospective multicenter cohort study of differences in clinical characteristics of Infantile Hemangiomas in preterm and term infants: Prematurity increases risk of permanent cutaneous sequelae.

IF 12.8 1区医学 Q1 DERMATOLOGY

Journal of the American Academy of Dermatology Pub Date : 2024-10-23 DOI:10.1016/j.jaad.2024.09.066

Flora E Bradley, Esteban Fernández Faith, Sonal D Shah, Mitchell Braun, Elena Pope, Irene Lara-Corrales, Patricia M Witman, Katya Harfmann, Amy Buros Stein, Ilona J Frieden

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引用次数: 0

Abstract

Background: We observed many preterm infants with unexpectedly thick infantile hemangiomas (IH), a subtype known to be associated with increased risk of scarring.

Objective: To compare the clinical features of localized IH in preterm versus term infants.

Methods: A retrospective study at three tertiary referral centers was conducted on 830 consecutive patients with localized IH.

Results: Preterm infants had a significantly higher incidence of superficial IH (75% in <33weeks, 57% in 33-<37 weeks, and 50% in term infants, p=0.007). Overall, their IH had thicker superficial components (p<0.001) and more stepped borders (p<0.001). These features correlated with the degree of prematurity. The average chronological age at presentation to the specialist was 5.6 (SD=6.2) months, with no difference between gestational age.

Limitations: The retrospective design and use of non-standardized clinical photographs. There may be biases introduced toward more severe IH types because the study sites were tertiary referral centers.

Conclusion: Preterm infants have features of IH that have obvious implication for systemic therapies. Most of these infants were seen beyond the typical proliferative phase when irreversible skin changes may have already occurred.

查看原文本刊更多论文

早产儿和足月儿婴儿血管瘤临床特征差异的回顾性多中心队列研究：早产儿会增加永久性皮肤后遗症的风险。

背景：我们观察到许多早产儿患有意外增厚的婴儿血管瘤（IH），这种亚型已知与瘢痕风险增加有关：比较早产儿与足月儿局部 IH 的临床特征：方法：在三家三级转诊中心对连续 830 例局部 IH 患者进行了回顾性研究：结果：早产儿浅表 IH 的发病率明显更高（75%）：局限性：采用回顾性设计和非标准化临床照片。由于研究地点是三级转诊中心，因此可能存在偏向于更严重类型的 IH 的情况：早产儿的 IH 特征对全身疗法有明显影响。这些婴儿中的大多数已超过了典型的增殖期，此时皮肤可能已发生不可逆的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Academy of Dermatology 医学-皮肤病学

CiteScore

8.60

自引率

5.80%

发文量

2023

审稿时长

49 days

期刊介绍： The Journal of the American Academy of Dermatology (JAAD) is the official scientific publication of the American Academy of Dermatology (AAD). Its primary goal is to cater to the educational requirements of the dermatology community. Being the top journal in the field, JAAD publishes original articles that have undergone peer review. These articles primarily focus on clinical, investigative, and population-based studies related to dermatology. Another key area of emphasis is research on healthcare delivery and quality of care. JAAD also highlights high-quality, cost-effective, and innovative treatments within the field. In addition to this, the journal covers new diagnostic techniques and various other topics relevant to the prevention, diagnosis, and treatment of skin, hair, and nail disorders.