Sex, Racial/Ethnic, and Regional Disparities in Pulmonary Embolism Mortality Trends in the USA, 1999-2020.

IF 3.2 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Racial and Ethnic Health Disparities Pub Date : 2024-10-25 DOI:10.1007/s40615-024-02197-5

Greta Muriel Eikermann, Christopher Tam, Annika Eyth, Can Martin Ludeke, Aline M Grimme, Tina Ramishvili, Felix Borngaesser, Maira Rudolph, Nicole Aber, Sandra Emily Stoll, Corinne M Kyriacou, Fran A Ganz-Lord, Ibraheem M Karaye

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引用次数: 0

Abstract

Background: While the National Institutes of Health emphasize integrating sex as a biological variable into research, specific considerations of sex-related differences in pulmonary embolism (PE) mortality trends remain scarce. This study examines sex-based PE mortality trends across regional and demographic groups in the USA from 1999 to 2020.

Methods: A retrospective analysis of National Center for Health Statistics mortality data from 1999 to 2020 was conducted. Using ICD-10 code I26, PE decedents were identified. Piecewise linear regression assessed sex-based temporal trends in PE mortality by age, race/ethnicity, and census region. Annual percentage changes and average annual percentage changes were derived using Weighted Bayesian Information Criteria. The 95% confidence intervals were estimated using the empirical quantile method.

Results: From 1999 to 2020, a total of 179,273 individuals died in the USA due to PE, resulting in an age-adjusted mortality rate of 2.5 per 100,000 persons (95% CI, 2.5-2.5). While men and women exhibited comparable rates in recent time segments and across most subcategories, a higher mortality trend among males compared to females was observed among non-Hispanic White and Hispanic individuals and residents of the Western US census region. These results remained robust even after excluding data from 2020, accounting for the potential impact of the COVID-19 pandemic.

Conclusions: Our study highlights sex-based disparities in PE mortality trends in the USA from 1999 to 2020. Despite overall stable mortality rates, higher trends among males were evident in specific demographic groups and regions. These findings emphasize the importance of targeted interventions to mitigate PE-related mortality discrepancies across diverse populations.

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1999-2020 年美国肺栓塞死亡率趋势中的性别、种族/族裔和地区差异。

背景：尽管美国国立卫生研究院强调将性别作为生物变量纳入研究，但对肺栓塞（PE）死亡率趋势中与性别有关的差异的具体考虑仍然很少。本研究探讨了 1999 年至 2020 年美国不同地区和人口群体中基于性别的肺栓塞死亡率趋势：方法：对美国国家卫生统计中心 1999 年至 2020 年的死亡率数据进行了回顾性分析。通过 ICD-10 代码 I26，确定了 PE 死者。分段线性回归按年龄、种族/人种和人口普查地区评估了基于性别的 PE 死亡率的时间趋势。使用加权贝叶斯信息标准得出年度百分比变化和平均年度百分比变化。95% 的置信区间采用经验量值法估算：从 1999 年到 2020 年，美国共有 179 273 人死于 PE，经年龄调整后的死亡率为每 10 万人 2.5 例（95% CI，2.5-2.5）。虽然在最近的时间段和大多数子类别中，男性和女性的死亡率相当，但在非西班牙裔白人、西班牙裔人和美国西部人口普查地区的居民中，观察到男性死亡率高于女性的趋势。即使剔除 2020 年的数据，考虑到 COVID-19 大流行的潜在影响，这些结果仍然保持稳定：我们的研究强调了 1999 年至 2020 年美国 PE 死亡率趋势中基于性别的差异。尽管总体死亡率保持稳定，但在特定人口群体和地区，男性的死亡率趋势明显较高。这些发现强调了采取有针对性的干预措施以减少不同人群中与 PE 相关的死亡率差异的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Racial and Ethnic Health Disparities PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

7.30

自引率

5.10%

发文量

263

期刊介绍： Journal of Racial and Ethnic Health Disparities reports on the scholarly progress of work to understand, address, and ultimately eliminate health disparities based on race and ethnicity. Efforts to explore underlying causes of health disparities and to describe interventions that have been undertaken to address racial and ethnic health disparities are featured. Promising studies that are ongoing or studies that have longer term data are welcome, as are studies that serve as lessons for best practices in eliminating health disparities. Original research, systematic reviews, and commentaries presenting the state-of-the-art thinking on problems centered on health disparities will be considered for publication. We particularly encourage review articles that generate innovative and testable ideas, and constructive discussions and/or critiques of health disparities.Because the Journal of Racial and Ethnic Health Disparities receives a large number of submissions, about 30% of submissions to the Journal are sent out for full peer review.