The Impact of Standard Cross-Linking on the Corneal Optical Density-Age Relationship in Keratoconus After Mechanical Stripping of the Epithelium.

IF 1.8 4区 医学 Q3 OPHTHALMOLOGY
Journal of Ophthalmology Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI:10.1155/2024/8827837
Maja Bohac, Fanka Gilevska, Alma Biscevic, Ivan Gabric, Kresimir Gabric, Sudi Patel
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引用次数: 0

Abstract

Background: To determine if cross-linking (CXL) treatment modifies any pre-existing association between corneal optical density (COD) and age in keratoconus free of corneal scarring. Methods: COD was monitored in two groups (i) before and after standard CXL treatment for keratoconus (de-epithelization with a crescent blade, n = 69 eyes) and (ii) age/gender-matched cases without any signs of keratoconus (n = 24 eyes). Seven different markers of COD were quantified using a 0-100 grey scale, supplied with Pentacam™ software. Results: Mean age (±sd, range) in Group I (19 females and 50 males) was 24.2 years (±7.2, 11-44) and in Group II (9 females and 15 males), it was 24.7 years (±7.6, 17-45). COD over the apex and along the depth of the cornea (y, arbitrary scale units) was associated with age (x, in years) in Group I at preop (y = 0.08x + 13.12, r s  = 0.350 and p=0.003), at 12 months postop (y = 0.08x + 15.15, r s  = 0.295 and p=0.014) and in Group II, at the start (y = 0.16x + 11.28, r s  = 0.474 and p=0.019) and 12 months later (y = 0.24x + 8.63, r s  = 0.600 and p=0.002). The change in COD following CXL was significantly associated with the preop value. Conclusion: CXL initially breaks down the pre-existing relationship between COD and age. This is re-established by 12 months postop. The CXL induced change in COD depends on the preop value but not on the patient's age.

角膜上皮机械剥离后标准交联对角膜光学密度-年龄关系的影响
背景:目的:确定交联(CXL)治疗是否会改变无角膜瘢痕的角膜炎患者的角膜光学密度(COD)与年龄之间预先存在的关联。方法:在两组患者中监测角膜光学密度:(i) 角膜炎标准 CXL 治疗前后(用新月形刀片去除角膜上皮,n = 69 只眼睛);(ii) 年龄/性别匹配、无任何角膜炎迹象的病例(n = 24 只眼睛)。使用 Pentacam™ 软件提供的 0-100 灰度计对七个不同的 COD 标记进行量化。结果第一组(19 名女性和 50 名男性)的平均年龄(±sd,范围)为 24.2 岁(±7.2,11-44 岁),第二组(9 名女性和 15 名男性)的平均年龄为 24.7 岁(±7.6,17-45 岁)。角膜顶点和角膜深度的 COD(y,任意刻度单位)与年龄(x,以岁为单位)相关,第一组在术前为(y = 0.08x + 13.12,r s = 0.350,p=0.003),在术后 12 个月为(y = 0.08x + 15.15,r s = 0.295,p=0.014),II 组在开始时(y = 0.16x + 11.28,r s = 0.474,p=0.019)和 12 个月后(y = 0.24x + 8.63,r s = 0.600,p=0.002)。CXL 后 COD 的变化与术前值有显著相关性。结论:CXL 最初会打破原有的角膜屈光度与年龄之间的关系。这种关系在术后 12 个月时重新建立。CXL 引起的角膜屈光度变化取决于术前值,而与患者的年龄无关。
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来源期刊
Journal of Ophthalmology
Journal of Ophthalmology MEDICINE, RESEARCH & EXPERIMENTAL-OPHTHALMOLOGY
CiteScore
4.30
自引率
5.30%
发文量
194
审稿时长
6-12 weeks
期刊介绍: Journal of Ophthalmology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the anatomy, physiology and diseases of the eye. Submissions should focus on new diagnostic and surgical techniques, instrument and therapy updates, as well as clinical trials and research findings.
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