Safety and efficacy of intravitreal dexamethasone implantation along with phacoemulsification and intraocular lens implantation in children with uveitis.

IF 2.9 Q1 OPHTHALMOLOGY
Hui Feng, Weixin Chen, Jianzhu Yang, Haorong Kong, Hongyu Li, Meng Tian, Jing Mo, Yuan He, Hong Wang
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Abstract

Purpose: To evaluate the safety and efficacy of intravitreal dexamethasone implantation during phacoemulsification and intraocular lens implantation in pediatric uveitis.

Methods: A retrospective analysis was conducted on pediatric uveitis patients undergoing phacoemulsification and intraocular lens implantation with intravitreal dexamethasone implantation. Patients with a minimum follow-up of 6 months were included. Primary outcome measures included ocular inflammation, intraocular pressure (IOP), best-corrected visual acuity (BCVA), and worsening of uveitis.

Results: 36 eyes of 28 patients were ultimately included in this study. The mean preoperative BCVA was 1.00 (0.40-1.50) LogMAR. BCVA significantly improved to 0.40 (0.20-0.54) LogMAR at 1 month postoperatively (P = 0.006), further improving to 0.30 (0.20-0.40) LogMAR at 3 months postoperatively (P = 0.001). BCVA remained stable at 0.30 (0.20-0.70) LogMAR at 6 months postoperatively (P = 0.005). Mean IOP showed no statistically significant difference during the follow-up period of three to six months after surgery. Eight children experienced recurrence of ocular inflammation during the 6-month follow-up period. No cases of worsening macular edema, glaucoma, or elevated IOP were observed in any patient.

Conclusion: Intravitreal dexamethasone implantation during phacoemulsification and intraocular lens implantation is a safe and effective method for preventing and treating postoperative inflammation in children with uveitis.

在葡萄膜炎儿童中进行玻璃体内地塞米松植入术以及超声乳化术和眼内人工晶体植入术的安全性和有效性。
目的:评估在小儿葡萄膜炎患者接受超声乳化术和眼内人工晶体植入术期间植入玻璃体内地塞米松的安全性和有效性:对接受超声乳化和眼内人工晶体植入术的小儿葡萄膜炎患者进行回顾性分析。患者的随访时间至少为 6 个月。主要结果指标包括眼部炎症、眼压(IOP)、最佳矫正视力(BCVA)和葡萄膜炎恶化:本研究最终纳入了 28 名患者的 36 只眼睛。术前 BCVA 的平均值为 1.00 (0.40-1.50) LogMAR。术后 1 个月,BCVA 明显改善至 0.40 (0.20-0.54) LogMAR(P = 0.006),术后 3 个月进一步改善至 0.30 (0.20-0.40) LogMAR(P = 0.001)。术后 6 个月时,BCVA 稳定在 0.30 (0.20-0.70) LogMAR(P = 0.005)。术后三到六个月的随访期间,平均眼压没有明显的统计学差异。在 6 个月的随访期间,有 8 名患儿的眼部炎症复发。没有发现任何患者出现黄斑水肿恶化、青光眼或眼压升高的情况:结论:在超声乳化和眼内人工晶体植入术中植入地塞米松是预防和治疗葡萄膜炎患儿术后炎症的一种安全有效的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.80
自引率
3.40%
发文量
39
审稿时长
13 weeks
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