Association between inflammation indicators (MLR, NLR, SII, SIRI, and AISI) and erectile dysfunction in US adults: NHANES 2001-2004.

IF 2.4 3区 医学 Q3 ENVIRONMENTAL SCIENCES
Heng Liu, Huqiang Dong, Mixue Guo, Hongping Cheng
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引用次数: 0

Abstract

Background: This study aimed to assess the relationship between multiple indicators of inflammation and erectile dysfunction through an analysis of data from the National Health and Nutrition Examination Survey (NHANES). This represents the first large-scale, cross-sectional investigation that explores this association by jointly analyzing various inflammatory markers.

Methods: We performed a cross-sectional analysis with NHANES data from 2001 to 2004. Erectile dysfunction (ED) was evaluated through a self-reported questionnaire and testosterone levels, while inflammatory markers were derived from standard blood test parameters. Our approach included multivariate logistic regression, subgroup analyses, generalized additive modeling (GAM), and smoothed curve fitting to evaluate the link between inflammatory markers (NLR, MLR, SII, SIRI, AISI) and ED. Additionally, we utilized receiver operating characteristic (ROC) curves to determine the diagnostic utility of these markers, comparing their area under the curve (AUC) values.

Results: A total of 3610 participants were included in this study, and the population-weighted ED patients were 18.91%. In the adjusted model, multiple logistic regression analysis showed a positive association between five inflammatory indicators (Ln-NLR, Ln-MLR, Ln-SII, Ln-SIRI, and Ln-AISI) and ED. Smoothed curve fitting showed a nonlinear positive correlation between the five inflammatory indicators and ED. Furthermore, subgroup analyses showed that this correlation was stronger in people older than 50 year. ROC curve analysis showed the highest diagnostic performance for the study outcome with MLR (AUC = 0.616, 95% CI: 0.5952-0.637), which was significantly better than SIRI, NLR, AISI, and SII.

Conclusion: MLR is potentially more effective than other biomarkers (NLR, SIRI, AISI, SII) in predicting ED. Men with elevated MLR levels should be particularly aware of their increased risk of developing ED.

美国成年人的炎症指标(MLR、NLR、SII、SIRI 和 AISI)与勃起功能障碍之间的关系:Nhanes 2001-2004.
研究背景本研究旨在通过分析美国国家健康与营养调查(NHANES)的数据,评估多种炎症指标与勃起功能障碍之间的关系。这是首次通过联合分析各种炎症指标来探讨这种关系的大规模横断面调查:我们对 2001 年至 2004 年的 NHANES 数据进行了横断面分析。勃起功能障碍(ED)通过自我报告问卷和睾酮水平进行评估,而炎症标志物则通过标准血液测试参数得出。我们的方法包括多变量逻辑回归、亚组分析、广义加法模型(GAM)和平滑曲线拟合,以评估炎症指标(NLR、MLR、SII、SIRI、AISI)与 ED 之间的联系。此外,我们还利用接收器操作特征曲线(ROC)来确定这些标记物的诊断效用,比较它们的曲线下面积(AUC)值:本研究共纳入 3610 名参与者,其中 ED 患者占人口加权的 18.91%。在调整模型中,多元逻辑回归分析表明五种炎症指标(Ln-NLR、Ln-MLR、Ln-SII、Ln-SIRI 和 Ln-AISI)与 ED 呈正相关。平滑曲线拟合显示,五项炎症指标与 ED 之间呈非线性正相关。此外,亚组分析表明,50 岁以上人群的相关性更强。ROC曲线分析显示,MLR对研究结果的诊断性能最高(AUC = 0.616,95% CI:0.5952-0.637),明显优于SIRI、NLR、AISI和SII:结论:在预测 ED 方面,MLR 可能比其他生物标志物(NLR、SIRI、AISI、SII)更有效。MLR水平升高的男性应特别注意其罹患ED的风险增加。
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来源期刊
Journal of Health, Population, and Nutrition
Journal of Health, Population, and Nutrition 医学-公共卫生、环境卫生与职业卫生
CiteScore
2.20
自引率
0.00%
发文量
49
审稿时长
6 months
期刊介绍: Journal of Health, Population and Nutrition brings together research on all aspects of issues related to population, nutrition and health. The journal publishes articles across a broad range of topics including global health, maternal and child health, nutrition, common illnesses and determinants of population health.
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