Air pollutants, residential greenspace, and the risk of kidney stone disease: a large prospective cohort study from the UK Biobank.

IF 4.1 3区医学 Q2 ENVIRONMENTAL SCIENCES

Journal of Exposure Science and Environmental Epidemiology Pub Date : 2024-10-22 DOI:10.1038/s41370-024-00728-0

Minghui Liu, Meng Gao, Zewu Zhu, Jiao Hu, Jian Wu, Hequn Chen, Xiaogen Kuang, Jinbo Chen

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引用次数: 0

Abstract

Background: The epidemiological evidence regarding the correlation between air pollution, residential greenspace, and the risk of kidney stone disease (KSD) is limited, with no large-scale prospective studies conducted on this relationship.

Objective: We conducted a large-scale prospective study from the UK Biobank to explore the correlation between air pollution, residential greenspace, and the risk of KSD.

Methods: This study included 419,835 UK Biobank participants who did not have KSD at baseline. An air pollution score was derived through the summation of concentrations for five air pollutants, including particulate matter (PM) with aerodynamic diameter ≤2.5 μm (PM_2.5), ranging from 2.5 to 10 μm (PM_2.5-10), ≤10 μm (PM₁₀), nitrogen dioxide (NO₂), and nitrogen oxides (NO_x). Various covariates were adjusted for in Cox proportional hazard regression to evaluate the risk of KSD associated with air pollution score, single air pollutant, and residential greenspace.

Results: During a follow-up period of 12.7 years, 4503 cases of KSD were diagnosed. Significant associations were found between KSD risk and air pollution score (HR: 1.08, 95% CI: 1.03-1.13), PM_2.5 (1.06, 1.02-1.11), PM₁₀ (1.04, 1.01-1.07), NO₂ (1.09, 1.02-1.16), NO_x (1.08, 1.02-1.11), greenspace buffered at 300 m (0.95, 0.91-0.99), and greenspace buffered at 1000 m (0.92, 0.86-0.98) increase per interquartile range (IQR). PM_2.5 and NO₂ reductions may be a key mechanism for the protective impact of residential greenspace on KSD (P _{for indirect path} < 0.05).

Impact: Prolonged exposure to air pollution was correlated with a higher risk of KSD, while residential greenspace exhibits an inverse association with KSD risk, partially mediated by the reduction in air pollutants concentrations. These findings emphasize the significance of mitigating air pollution and maintaining substantial greenspace exposure as preventive measures against KSD.

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空气污染物、住宅绿地与肾结石疾病风险：英国生物库的一项大型前瞻性队列研究。

背景：有关空气污染、居住区绿地和肾结石病（KSD）风险之间相关性的流行病学证据有限，目前尚未就这一关系开展大规模前瞻性研究：我们在英国生物库中开展了一项大规模前瞻性研究，以探讨空气污染、居住绿地与 KSD 风险之间的相关性：这项研究包括 419,835 名基线时未患有 KSD 的英国生物库参与者。通过对五种空气污染物（包括空气动力学直径≤2.5 μm的颗粒物（PM2.5）、2.5-10 μm的颗粒物（PM2.5-10）、≤10 μm的颗粒物（PM10）、二氧化氮（NO2）和氮氧化物（NOx））的浓度求和，得出空气污染评分。在考克斯比例危险回归中对各种协变量进行了调整，以评估与空气污染评分、单一空气污染物和居住绿地相关的KSD风险：结果：在 12.7 年的随访期间，共诊断出 4503 例 KSD。研究发现，KSD 风险与空气污染评分（HR：1.08，95% CI：1.03-1.13）、PM2.5（1.06，1.02-1.11）、PM10（1.04，1.01-1.07）、二氧化氮（1.09，1.02-1.16）、氮氧化物（1.08，1.02-1.11）、300 米处缓冲绿地（0.95，0.91-0.99）和 1000 米处缓冲绿地（0.92，0.86-0.98）每四分位数间距（IQR）增加。PM2.5和二氧化氮的减少可能是居住区绿地对KSD产生保护性影响的关键机制（P为间接路径影响）：长期暴露于空气污染与较高的 KSD 风险相关，而居住区绿地与 KSD 风险呈反向关系，部分原因是空气污染物浓度的降低。这些发现强调了减轻空气污染和保持大量绿地暴露作为 KSD 预防措施的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Exposure Science and Environmental Epidemiology 医学-毒理学

CiteScore

8.90

自引率

6.70%

发文量

审稿时长

3 months

期刊介绍： Journal of Exposure Science and Environmental Epidemiology (JESEE) aims to be the premier and authoritative source of information on advances in exposure science for professionals in a wide range of environmental and public health disciplines. JESEE publishes original peer-reviewed research presenting significant advances in exposure science and exposure analysis, including development and application of the latest technologies for measuring exposures, and innovative computational approaches for translating novel data streams to characterize and predict exposures. The types of papers published in the research section of JESEE are original research articles, translation studies, and correspondence. Reported results should further understanding of the relationship between environmental exposure and human health, describe evaluated novel exposure science tools, or demonstrate potential of exposure science to enable decisions and actions that promote and protect human health.