A case of epithelioid glioblastoma with lung metastases in a young Cane Corso dog

IF 0.8 4区 农林科学 Q4 PATHOLOGY
Yannick Van de Weyer, Emanuele Ricci, Gail Leeming
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引用次数: 0

Abstract

Astrocytomas are relatively common primary brain tumours of humans and companion animals. In dogs, they represent approximately 17–28% of primary central nervous system tumours. However, extracranial metastasis is extremely rare. This case report describes a grade IV astrocytoma (glioblastoma) in the cerebrum of a young Cane Corso dog with pulmonary metastases. The diagnosis was obtained via histopathological morphology and immunophenotyping, which showed strong positivity for glial fibrillary acidic protein, vimentin and connexin-43. The glioblastoma in this Cane Corso had epithelioid morphology with histological features of malignancy including high mitotic count, microvascular proliferation, serpentine necrosis and subventricular zone involvement. Epithelioid glioblastoma is a rare subtype that has only relatively recently been formally acknowledged in human medicine and it can also pose a diagnostic challenge in veterinary medicine.
一例上皮样胶质母细胞瘤伴肺转移的年轻肯恩柯索犬病例。
星形细胞瘤是人类和伴侣动物比较常见的原发性脑肿瘤。在狗的中枢神经系统原发性肿瘤中,星形细胞瘤约占 17-28%。然而,颅外转移却极为罕见。本病例报告描述了一只年轻肯恩柯索犬脑部的 IV 级星形细胞瘤(胶质母细胞瘤),并伴有肺转移。诊断是通过组织病理形态学和免疫分型获得的,免疫分型显示胶质纤维酸性蛋白、波形蛋白和连接蛋白-43呈强阳性。该肯恩科索犬的胶质母细胞瘤呈上皮样形态,具有恶性肿瘤的组织学特征,包括高有丝分裂计数、微血管增生、蛇形坏死和室管膜下区受累。上皮样胶质母细胞瘤是一种罕见的亚型,直到最近才被人类医学正式承认,它也会给兽医诊断带来挑战。
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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
208
审稿时长
50 days
期刊介绍: The Journal of Comparative Pathology is an International, English language, peer-reviewed journal which publishes full length articles, short papers and review articles of high scientific quality on all aspects of the pathology of the diseases of domesticated and other vertebrate animals. Articles on human diseases are also included if they present features of special interest when viewed against the general background of vertebrate pathology.
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