Lecithin-based mixed polymeric micelles for activity improvement of curcumin against Staphylococcus aureus.

IF 3.6 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-10-26 DOI:10.1080/09205063.2024.2421089

Yunjing Jia, Yuli Li, Mingzhu Wang, Fuyou Wang, Qingmin Liu, Zhimei Song

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引用次数: 0

Abstract

Considering cellular uptake promotion of lecithin and high expression of phospholipase in S. aureus, we designed curcumin (Cur)-loaded soy lecithin-based mPEG-PVL copolymer micelles (MPPC). The effect of soy lecithin on the anti-S. aureus activity of the formulation was studied with cur-loaded mPEG-PVL micelles (MPC without soy lecithin) as control. It was found that MPPC enhanced the water-solubility of Cur, and showed slow and sustained release behavior of Cur. Although MPPC had the same anti-S. aureus activity as Cur, its activity was significantly higher than MPC due to the cellular uptake promotion of soybean lecithin. It was noted that MPPC had good inhibition or destruction effect on biofilm, significant cell membrane damage, strong inhibition effect on protease or lipase production, and obvious induction effect on ROS expression when compared with Cur and MPC. So, the introduction of soy lecithin could improve the antibacterial activity of Cur. The lecithin-based micelles would offer potential to deliver antibacterial drugs for improved therapeutic action.

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基于卵磷脂的混合聚合物胶束用于提高姜黄素对金黄色葡萄球菌的活性。

考虑到卵磷脂对细胞吸收的促进作用以及金黄色葡萄球菌磷脂酶的高表达，我们设计了姜黄素（Cur）负载大豆卵磷脂的 mPEG-PVL 共聚物胶束（MPPC）。以姜黄素负载的 mPEG-PVL 胶束（不含大豆卵磷脂的 MPC）为对照，研究了大豆卵磷脂对制剂抗金黄色葡萄球菌活性的影响。结果发现，MPPC 提高了 Cur 的水溶性，并显示出 Cur 的缓释和持续释放行为。虽然 MPPC 与 Cur 具有相同的抗金黄色葡萄球菌活性，但由于大豆卵磷脂促进了细胞吸收，其活性明显高于 MPC。研究指出，与 Cur 和 MPC 相比，MPPC 对生物膜有良好的抑制或破坏作用，对细胞膜有明显的破坏作用，对蛋白酶或脂肪酶的产生有较强的抑制作用，对 ROS 的表达有明显的诱导作用。因此，引入大豆卵磷脂可以提高 Cur 的抗菌活性。以卵磷脂为基础的胶束有可能输送抗菌药物，提高治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomaterials Science, Polymer Edition 工程技术-材料科学：生物材料

CiteScore

7.10

自引率

5.60%

发文量

117

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels. The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.