Cerebral cortex changes in FD, IBS, and GERD: A Mendelian randomization study.

IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY
Journal of affective disorders Pub Date : 2025-01-15 Epub Date: 2024-10-22 DOI:10.1016/j.jad.2024.10.057
Kai-Yue Huang, Jia-Yan Hu, Mi Lv, Feng-Yun Wang, Xiang-Xue Ma, Xu-Dong Tang, Lin Lv
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引用次数: 0

Abstract

Background: Prospective and cross-sectional studies have reported an association between functional gastrointestinal disorders and anxiety and depression. However, the causal relationship remains uncertain. To clarify this, we utilized Mendelian randomization (MR) to assess the causal effects of common gastrointestinal disorders on cortical structures.

Methods: Genome-wide association study (GWAS) data was gathered for functional dyspepsia (FD), irritable bowel syndrome (IBS), and gastroesophageal reflux disease (GERD) from European populations numbering 329,262, 16,792, and 602,604, respectively. GWAS cerebral cortical architecture data for cortical thickness (TH) and surface area (SA) were obtained from 51,665 MRI scans. MR was used to analyze the casual relationship between FD, IBS, GERD, and cortical structures. Inverse-variance weighted, weighted median, and MR-Egger tests were performed as assessment indicators. We also evaluated heterogeneity and pleiotropy.

Results: FD significantly decreases the TH in the rostral anterior cingulate cortex (βTH = -0.022 mm; 95%CI: -0.035 mm to -0.009 mm2; PTH = 6.89 × 10-4), and IBS significantly decreases the SA of the pars triangularis (βSA = -21.91 mm2; 95%CI: -32.99 mm to -10.83 mm2; PSA = 1.06 × 10-4), precuneus (βSA = -47.53 mm2; 95%CI: -73.57 mm to-21.48 mm2; PSA = 3.48 × 10-4) and superior frontal regions (βSA = -78.70 mm2; 95%CI: -122.61 mm to -34.78 mm2; PSA = 4.4 × 10-4). At the local functional level, GERD significantly increases the SA of the inferior temporal region (βSA = -113.58 mm2, 95%CI: -113.58 mm to -39.01 mm2, PSA = 6.05 × 10-5).

Conclusions: FD, IBS and GERD can affect the cerebral cortex architecture through the brain-gut axis, potentially increasing the risks of mental illness and cognitive impairment.

FD、肠易激综合征和胃食管反流病的大脑皮层变化:孟德尔随机研究
背景:有前瞻性和横断面研究报告称,功能性胃肠病与焦虑和抑郁之间存在关联。然而,其中的因果关系尚不清楚。因此,我们采用孟德尔随机法(MR)来确定常见胃肠功能紊乱对大脑皮层结构的因果影响:方法:我们分别从 329 262、16 792 和 602 604 名欧洲人中获得了功能性消化不良(FD)、肠易激综合征(IBS)和胃食管反流病(GERD)的全基因组关联研究(GWAS)数据。GWAS 大脑皮层结构数据包括皮层厚度 (TH) 和表面积 (SA),这些数据来自 51,665 次核磁共振扫描。磁共振成像用于分析FD、肠易激综合征、胃食管反流病与皮层结构之间的偶然关系。作为评估指标,进行了反方差加权、加权中位数和 MR-Egger 检验。我们还评估了异质性和多义性:结果发现,FD会显著降低喙突前扣带回皮层的TH(βTH = -0.022 mm; 95%CI: -0.035 mm to -0.009 mm2; PTH = 6.89 × 10-4),IBS会显著降低三角旁的SA(βSA = -21.91 mm2; 95%CI: -32.99 mm to -10.83 mm2; PSA = 1.06 × 10-4)、楔前区(βSA = -47.53 mm2; 95%CI: -73.57 mm to-21.48 mm2; PSA = 3.48 × 10-4)和额上区(βSA = -78.70 mm2; 95%CI: -122.61 mm to -34.78 mm2; PSA = 4.4 × 10-4)。在局部功能水平上,胃食管反流病显著增加了下颞区的 SA(βSA = -113.58 mm2,95%CI:-113.58 mm 至 -39.01 mm2,PSA = 6.05 × 10-5):FD、肠易激综合征和胃食管反流病可通过脑-肠轴影响大脑皮层结构,从而增加罹患精神疾病和认知功能障碍的风险。
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来源期刊
Journal of affective disorders
Journal of affective disorders 医学-精神病学
CiteScore
10.90
自引率
6.10%
发文量
1319
审稿时长
9.3 weeks
期刊介绍: The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.
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