Ten challenges and opportunities in computational immuno-oncology.

IF 10.3 1区医学 Q1 IMMUNOLOGY

Journal for Immunotherapy of Cancer Pub Date : 2024-10-26 DOI:10.1136/jitc-2024-009721

Riyue Bao, Alan Hutson, Anant Madabhushi, Vanessa D Jonsson, Spencer R Rosario, Jill S Barnholtz-Sloan, Elana J Fertig, Himangi Marathe, Lyndsay Harris, Jennifer Altreuter, Qingrong Chen, James Dignam, Andrew J Gentles, Edgar Gonzalez-Kozlova, Sacha Gnjatic, Erika Kim, Mark Long, Martin Morgan, Eytan Ruppin, David Van Valen, Hong Zhang, Natalie Vokes, Daoud Meerzaman, Song Liu, Eliezer M Van Allen, Yi Xing

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引用次数: 0

Abstract

Immuno-oncology has transformed the treatment of cancer, with several immunotherapies becoming the standard treatment across histologies. Despite these advancements, the majority of patients do not experience durable clinical benefits, highlighting the imperative for ongoing advancement in immuno-oncology. Computational immuno-oncology emerges as a forefront discipline that draws on biomedical data science and intersects with oncology, immunology, and clinical research, with the overarching goal to accelerate the development of effective and safe immuno-oncology treatments from the laboratory to the clinic. In this review, we outline 10 critical challenges and opportunities in computational immuno-oncology, emphasizing the importance of robust computational strategies and interdisciplinary collaborations amid the constantly evolving interplay between clinical needs and technological innovation.

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计算免疫肿瘤学的十大挑战与机遇。

免疫肿瘤学改变了癌症的治疗方法，几种免疫疗法已成为不同组织的标准治疗方法。尽管取得了这些进步，但大多数患者并没有获得持久的临床疗效，这凸显了免疫肿瘤学不断进步的必要性。计算免疫肿瘤学是一门前沿学科，它借鉴了生物医学数据科学，并与肿瘤学、免疫学和临床研究相互交叉，其总体目标是加速开发从实验室到临床的有效、安全的免疫肿瘤治疗方法。在这篇综述中，我们概述了计算免疫肿瘤学的 10 个关键挑战和机遇，强调了在临床需求和技术创新之间不断发展的相互作用中，强大的计算策略和跨学科合作的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal for Immunotherapy of Cancer Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

17.70

自引率

4.60%

发文量

522

审稿时长

18 weeks

期刊介绍： The Journal for ImmunoTherapy of Cancer (JITC) is a peer-reviewed publication that promotes scientific exchange and deepens knowledge in the constantly evolving fields of tumor immunology and cancer immunotherapy. With an open access format, JITC encourages widespread access to its findings. The journal covers a wide range of topics, spanning from basic science to translational and clinical research. Key areas of interest include tumor-host interactions, the intricate tumor microenvironment, animal models, the identification of predictive and prognostic immune biomarkers, groundbreaking pharmaceutical and cellular therapies, innovative vaccines, combination immune-based treatments, and the study of immune-related toxicity.