Intramuscular injection of a commercially available medetomidine-vatinoxan hydrochloride mixture produces reliable sedation in sheep and goats with varying cardiopulmonary effects.

IF 1.6 2区 农林科学 Q2 VETERINARY SCIENCES
Alaina A Kuehr, Andrew J T Muir, Chin-Chi Liu, Elizabeth J Benton-Levith, Clare M Scully, Jeannette Cremer
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引用次数: 0

Abstract

Objective: To evaluate the sedation quality of an IM injection of a commercially available medetomidine-vatinoxan combination (ZEN) in healthy goats and sheep and discern species differences in cardiopulmonary parameters.

Methods: 10 apparently healthy adult university-owned research Black Bengal-crossbreed goats and 10 adult Gulf Coast native and Katahdin sheep were enrolled in this prospective experimental study from June 27 to July 27, 2023. All animals were sedated on 1 occasion with 0.06 mL of ZEN/kg, IM (0.03 mg of medetomidine/kg and 0.6 mg of vatinoxan hydrochloride/kg). Cardiopulmonary variables including heart rate, arterial blood pressure, and arterial blood gas parameters were recorded along with sedation depth and duration. Any animals still sedated after 150 minutes received 0.01 mg of atipamezole/kg.

Results: The mean ± SD of the total sedation time for sheep and goats was 102.80 ± 10.90 minutes and 133.50 ± 32.63 minutes, respectively. Profound reliable sedation was achieved in all but 1 animal. Hypoxemia was observed in sheep and goats (11 of 20 animals total). Hypotension was seen in 3 of 10 goats.

Conclusions: In sheep and goats, ZEN at 0.06 mL/kg, IM, caused profound sedation. Total sedation time was significantly longer in goats than in sheep.

Clinical relevance: In the presence of oxygen supplementation, ZEN at 0.06 mL/kg, IM, may be an acceptable sedation choice for apparently healthy Gulf Coast native and Katahdin sheep, but not goats; however, preexisting hypokalemia or pulmonary disease are contraindications for the use of ZEN in sheep.

肌肉注射市售的盐酸美托咪啶-瓦替诺生混合物可对绵羊和山羊产生可靠的镇静作用,但对心肺功能的影响各不相同。
目的方法:2023 年 6 月 27 日至 7 月 27 日,10 只明显健康的成年大学研究用黑孟加拉杂交山羊和 10 只成年墨西哥湾沿岸原生绵羊和卡塔丁绵羊参加了这项前瞻性实验研究。所有动物均使用 0.06 mL ZEN/kg IM(0.03 mg 美托咪定/kg 和 0.6 mg 盐酸伐替诺生/kg)镇静 1 次。记录心肺变量,包括心率、动脉血压和动脉血气参数,以及镇静深度和持续时间。任何在 150 分钟后仍处于镇静状态的动物均接受 0.01 毫克阿替帕唑/千克的注射:结果:绵羊和山羊总镇静时间的平均值(± SD)分别为 102.80 ± 10.90 分钟和 133.50 ± 32.63 分钟。除 1 只动物外,其他动物均获得了可靠的镇静效果。在绵羊和山羊中观察到低氧血症(20 只动物中的 11 只)。10 只山羊中有 3 只出现了低血压:结论:在绵羊和山羊中,0.06 mL/kg IM剂量的ZEN可引起深度镇静。山羊的总镇静时间明显长于绵羊:临床意义:在补充氧气的情况下,0.06 mL/kg IM剂量的ZEN对明显健康的墨西哥湾沿岸原生绵羊和卡塔丁绵羊可能是一种可接受的镇静选择,但对山羊则不是;不过,绵羊使用ZEN的禁忌症是原有的低钾血症或肺部疾病。
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来源期刊
CiteScore
1.60
自引率
15.80%
发文量
539
审稿时长
6-16 weeks
期刊介绍: Published twice monthly, this peer-reviewed, general scientific journal provides reports of clinical research, feature articles and regular columns of interest to veterinarians in private and public practice. The News and Classified Ad sections are posted online 10 days to two weeks before they are delivered in print.
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