Prostate Specific Antigen (PSA) testing in a general practice 2009-2019.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Irish Journal of Medical Science Pub Date : 2024-10-23 DOI:10.1007/s11845-024-03804-4

Niall Maguire, Andrea Moloney, Krzysztof Fic

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引用次数: 0

Abstract

Background: Prostate-specific antigen (PSA) testing is not recommended as a population screening measure for prostate cancer. PSA testing is nevertheless widespread and is associated with harm due to false-positive test results, overdiagnosis and economic costs.

Aims: This study sought to document the exposure of patients to PSA testing over a decade in a general medical practice setting.

Methods: Laboratory results for each year were extracted from the clinical record. A chart review was undertaken for cases of prostate cancer.

Results: We report 13,743 PSA results in 3313 men. In any year, 18% of all men and 33% of men aged over 50 years had at least one PSA test. Between 4.8 and 21% of first tests exceeded age normal values depending on age. There were 113 incident cancers in the study interval of which 84 (74%) were screen detected. Mortality was lower in screen-detected than symptomatic cancers.

Conclusions: Men at our practice are significantly exposed to PSA testing. We found evidence of possible overdiagnosis.

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2009-2019 年普通诊所的前列腺特异抗原 (PSA) 检测。

背景：不建议将前列腺特异性抗原（PSA）检测作为前列腺癌的人群筛查措施。尽管如此，PSA检测仍在广泛使用，而且由于假阳性检测结果、过度诊断和经济成本等原因，PSA检测对人体造成了伤害。目的：本研究旨在记录普通医疗机构十年来患者接受PSA检测的情况：方法：从临床记录中提取每年的化验结果。方法：从临床记录中提取每年的化验结果，并对前列腺癌病例进行病历审查：我们报告了 3313 名男性的 13743 次 PSA 检测结果。在任何一年中，18% 的男性和 33% 的 50 岁以上男性至少进行过一次 PSA 检测。根据年龄的不同，4.8% 到 21% 的首次检测结果超过了年龄正常值。在研究区间内共有 113 例癌症，其中 84 例（74%）是通过筛查发现的。筛查出的癌症死亡率低于无症状癌症：结论：在我们的医疗机构中，男性接受 PSA 检测的比例很高。我们发现了可能存在过度诊断的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.