Characteristics of and Risk Factors for Depressive Symptoms Preceding Dementia: A Study of 82-Year-Old Men From the Uppsala Longitudinal Study of Adult Men

IF 3.6 3区医学 Q2 GERIATRICS & GERONTOLOGY

International Journal of Geriatric Psychiatry Pub Date : 2024-10-22 DOI:10.1002/gps.70000

Angelica Kallström, Vilmantas Giedraitis, Kristin Franzon, Malin Löwenmark, Lena Kilander, Gustaf Boström

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引用次数: 0

Abstract

Background

Depression and dementia are known to be associated. The identification of characteristics distinguishing depression prodromal to dementia from other depressive symptoms would be of value for early identification of dementia. The study of risk factors for depressive symptoms prodromal to dementia could improve preventive care and provide clues to the causes of dementia.

Method

Dementia-free 82-year-old participants were stratified into groups that did (n = 126) and did not (n = 378) subsequently develop dementia. Examinations took place from 2003 to 2005 and follow-up ended 1 January 2015. Their baseline characteristics and depressive symptoms, measured using the 15-item Geriatric Depression Scale (GDS-15), were compared. Multivariate regression analyses were performed for the two groups separately, with the total GDS-15 score as the dependent variable.

Results

The groups did not differ significantly in answers to any of the GDS-15 questions, or mean ± SD score, which was 2.4 ± 2.5 among those who developed dementia and 2.1 ± 2.3 among those who did not. (p = 0.33). Stroke before the age of 82 years and the inability to use stairs had significant impacts on the GDS-15 scores in both groups. For those who did not develop dementia, age, dependence in activities of daily living, and cancer also had significant impacts. Cancer had opposite associations with depressive symptoms in the two groups.

Conclusions

No difference was found in depressive symptoms preceding and not preceding dementia using the GDS-15. The results suggest that risk factors for depressive symptoms may differ depending on whether they precede dementia.

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痴呆症前抑郁症状的特征和风险因素：乌普萨拉成年男性纵向研究》（Uppsala Longitudinal Study of Adult Men）对 82 岁男性的研究。

背景：众所周知，抑郁症和痴呆症是相关联的。找出区别痴呆症前驱抑郁症和其他抑郁症状的特征对于早期识别痴呆症很有价值。研究痴呆症前驱抑郁症状的风险因素可以改善预防性护理，并为痴呆症的病因提供线索：方法：将无痴呆症的 82 岁参与者分为两组，一组后来患上痴呆症（126 人），另一组后来没有患上痴呆症（378 人）。检查时间为2003年至2005年，随访时间截至2015年1月1日。他们的基线特征和抑郁症状（使用 15 项老年抑郁量表 (GDS-15) 测量）进行了比较。以 GDS-15 总分为因变量，对两组分别进行了多变量回归分析：结果：两组患者对 GDS-15 任何问题的回答或平均得分（± SD）均无明显差异，痴呆症患者的平均得分为 2.4 ± 2.5，而非痴呆症患者的平均得分为 2.1 ± 2.3（P = 0.33）。(p = 0.33).82 岁前中风和无法使用楼梯对两组患者的 GDS-15 评分均有显著影响。对于未患痴呆症的人来说，年龄、日常生活活动依赖性和癌症也有显著影响。在两组患者中，癌症与抑郁症状的关系正好相反：结论：使用 GDS-15 测量，痴呆症发病前和未发病前的抑郁症状没有差异。结果表明，抑郁症状的风险因素可能因其是否先于痴呆症而有所不同。

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来源期刊

International Journal of Geriatric Psychiatry 医学-精神病学

CiteScore

6.10

自引率

2.50%

发文量

168

审稿时长

4-8 weeks

期刊介绍： The rapidly increasing world population of aged people has led to a growing need to focus attention on the problems of mental disorder in late life. The aim of the Journal is to communicate the results of original research in the causes, treatment and care of all forms of mental disorder which affect the elderly. The Journal is of interest to psychiatrists, psychologists, social scientists, nurses and others engaged in therapeutic professions, together with general neurobiological researchers. The Journal provides an international perspective on the important issue of geriatric psychiatry, and contributions are published from countries throughout the world. Topics covered include epidemiology of mental disorders in old age, clinical aetiological research, post-mortem pathological and neurochemical studies, treatment trials and evaluation of geriatric psychiatry services.