Sexual behaviors and risk of extended-spectrum β-lactamase-producing Enterobacterales carriage: A cross-sectional analysis

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2024-10-23 DOI:10.1016/j.ijid.2024.107277

Anders Boyd , Pauline Mathieu , Ugo Françoise , Hayette Rougier , Thibault Chiarabini , Nadia Valin , Karine Lacombe , Paul-Louis Woerther , Laure Surgers

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引用次数: 0

Abstract

Objectives

Sexual transmission of extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) is suspected. We aimed to identify clusters of sexual behavior associated with ESBL-E carriage among individuals at risk of sexually transmitted infections (STI).

Methods

In this cross-sectional study, patients attending an STI-screening center and human immunodeficiency virus outpatient clinic in Paris, France between 2018 and 2019 were asked questions on the following sexual activities in the last 6 months: receptive/insertive anal intercourse, passive/active rimming, receptive/insertive fellatio, receptive/insertive fisting, receptive/insertive fingering, active/passive cunnilingus. ESBL-E carriage was determined from rectal swabs. Bayesian latent class analysis was used to identify clusters of sexual activity, which were then associated with ESBL-E carriage using logistic regression.

Results

Among 1211 men who have sex with men (MSM), those belonging to two latent classes with higher prevalence of insertive fingering and active rimming (ESBL-E prevalence=15.3%, N = 124 and 16.0%, N = 100) and one class with higher proportions of all behaviors (24.3%, N = 70) had a higher risk of ESBL-E carriage compared to those in a class with few sexual behaviors (7.3%, N = 259) after adjustment. Among 439 other men and 479 women, no clear associations between sexual clusters and ESBL-E carriage were observed.

Conclusions

Sexual behaviors are associated with varying degrees of ESBL-E carriage, particularly among MSM.

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性行为与携带广谱β-内酰胺酶肠杆菌的风险：横断面分析。

目的：怀疑产扩谱β-内酰胺酶肠杆菌（ESBL-E）通过性传播。我们旨在确定性传播感染（STI）高危人群中与ESBL-E携带相关的性行为群：在这项横断面研究中，2018-2019年间在法国巴黎一家性传播疾病筛查中心和HIV门诊就诊的患者被问及过去6个月中的以下性行为：接受性/插入性肛交、被动/主动舔阴、接受性/插入性口交、接受性/插入性握拳、接受性/插入性指交、主动/被动舔阴。通过直肠拭子确定ESBL-E携带情况。贝叶斯潜类分析用于确定性活动群组，然后利用逻辑回归将其与ESBL-E携带相关联：结果：在1211名男男性行为者（MSM）中，经调整后，与性行为较少的人群（7.3%，N=259）相比，属于插入指法和主动舔阴（ESBL-E感染率分别为15.3%，N=124和16.0%，N=100）发生率较高的两个潜伏类群以及所有行为比例较高的一个类群（24.3%，N=70）的人群携带ESBL-E的风险较高。在其他439名男性和479名女性中，没有观察到性行为群组与ESBL-E携带之间有明显的关联：结论：性行为与不同程度的ESBL-E携带有关，尤其是在男男性行为者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.