Next-Generation Sequencing Reveals the Novel HLA-DQA1*06:01:04 Allele in a Bone Marrow Donor

IF 5.9 4区医学 Q2 CELL BIOLOGY

HLA Pub Date : 2024-10-27 DOI:10.1111/tan.15729

Ahmed Gaballa, Anna Söderström, Nina Lundin, Torsten Eich

引用次数: 0

Abstract

A single nucleotide mismatch within exon 2 of HLA-DQA1 differentiates the novel DQA1*06:01:04 allele from DQA1*06:01:01:01.

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下一代测序发现一名骨髓捐献者体内存在新型 HLA-DQA1*06:01:04 等位基因。

HLA-DQA1 外显子 2 中的单核苷酸错配将新型 DQA1*06:01:04 等位基因与 DQA1*06:01:01 区分开来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

HLA Immunology and Microbiology-Immunology

CiteScore

3.00

自引率

28.80%

发文量

368

期刊介绍： HLA, the journal, publishes articles on various aspects of immunogenetics. These include the immunogenetics of cell surface antigens, the ontogeny and phylogeny of the immune system, the immunogenetics of cell interactions, the functional aspects of cell surface molecules and their natural ligands, and the role of tissue antigens in immune reactions. Additionally, the journal covers experimental and clinical transplantation, the relationships between normal tissue antigens and tumor-associated antigens, the genetic control of immune response and disease susceptibility, and the biochemistry and molecular biology of alloantigens and leukocyte differentiation. Manuscripts on molecules expressed on lymphoid cells, myeloid cells, platelets, and non-lineage-restricted antigens are welcomed. Lastly, the journal focuses on the immunogenetics of histocompatibility antigens in both humans and experimental animals, including their tissue distribution, regulation, and expression in normal and malignant cells, as well as the use of antigens as markers for disease.