Sander Trenson, Peter C Kahr, Judith M Schwaiger, Pascal Betschart, Joël Kuster, Bert Vandenberk, Jürgen Duchenne, Ahmed S Beela, Ivan Stankovic, Gabor Voros, Andreas J Flammer, Matthias Schindler, Ardan M Saguner, Rik Willems, Frank Ruschitzka, Jan Steffel, Alexander Breitenstein, Jens-Uwe Voigt, Stephan Winnik
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引用次数: 0
Abstract
Background: Cardiac resynchronization therapy (CRT) is a cornerstone in the treatment of selected heart failure patients. However, a relevant proportion of patients do not show beneficial response. Identification of simple, additive, and outcome-relevant selection criteria may improve selection of patients.
Objective: We sought to determine whether baseline QRS amplitude is associated with outcome in CRT.
Methods: Quantification of intrinsic, pre-CRT implantation QRS amplitude was performed in an observational multinational 2-center retrospective cohort analysis (derivation cohort Zurich, n = 178, 2000-2015; validation cohort Leuven, n = 183, 1999-2016) with a composite end point of all-cause mortality, ventricular assist device implantation, or heart transplantation at 5 years.
Results: Higher baseline to peak amplitude in lateral leads (lead I and V6) was associated with a lower risk of reaching the composite end point (lead I: hazard ratio, 0.86 [95% confidence interval, 0.78-0.95] per millivolt, P = .002; lead V6: hazard ratio, 0.94 [95% confidence interval, 0.88-1.00] per millivolt, P = .043). Concordance index-based comparison of quartile, spline, and receiver operating characteristic curve analysis suggested cutoff values of 6 mV for lead I and 3 mV for V6 for optimal discrimination of outcome. External validation confirmed the cutoff of 3 mV in lead V6 as a highly significant discriminator of outcome (P < .001) associated with a risk reduction of 65%.
Conclusion: Low QRS amplitude in lateral electrocardiogram leads is associated with higher risk of poor outcome in CRT patients. A cutoff of 3 mV in lead V6 proved highly discriminative. Further studies need to confirm the additive value of QRS amplitude in selection of patients for CRT and to assess whether CRT may be made available to more patients.
期刊介绍:
HeartRhythm, the official Journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, is a unique journal for fundamental discovery and clinical applicability.
HeartRhythm integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community.
The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal health care policies and standards.