Misael de Azevedo Teotônio Cavalcanti, Karla Joane Da Silva Menezes, Jéssika De Oliveira Viana, Éric de Oliveira Rios, Arthur Gabriel Corrêa de Farias, Karen Cacilda Weber, Fatima Nogueira, Igor José Dos Santos Nascimento, Ricardo Olimpio de Moura
{"title":"Current trends to design antimalarial drugs targeting <i>N</i>-myristoyltransferase.","authors":"Misael de Azevedo Teotônio Cavalcanti, Karla Joane Da Silva Menezes, Jéssika De Oliveira Viana, Éric de Oliveira Rios, Arthur Gabriel Corrêa de Farias, Karen Cacilda Weber, Fatima Nogueira, Igor José Dos Santos Nascimento, Ricardo Olimpio de Moura","doi":"10.1080/17460913.2024.2412397","DOIUrl":null,"url":null,"abstract":"<p><p>Malaria is a disease caused by <i>Plasmodium</i> spp., of which <i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i> are the most prevalent. Unfortunately, traditional and some current treatment regimens face growing protozoan resistance. Thus, searching for and exploring new drugs and targets is necessary. One of these is <i>N</i>-myristoyltransferase (NMT). This enzyme is responsible for the myristoylation of several protein substrates in eukaryotic cells, including <i>Plasmodium</i> spp., thus enabling the assembly of protein complexes and stabilization of protein-membrane interactions. Given the importance of this target in developing new antiparasitic drugs, this review aims to explore the recent advances in the design of antimalarial drugs to target <i>Plasmodium</i> NMT.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/17460913.2024.2412397","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Malaria is a disease caused by Plasmodium spp., of which Plasmodium falciparum and Plasmodium vivax are the most prevalent. Unfortunately, traditional and some current treatment regimens face growing protozoan resistance. Thus, searching for and exploring new drugs and targets is necessary. One of these is N-myristoyltransferase (NMT). This enzyme is responsible for the myristoylation of several protein substrates in eukaryotic cells, including Plasmodium spp., thus enabling the assembly of protein complexes and stabilization of protein-membrane interactions. Given the importance of this target in developing new antiparasitic drugs, this review aims to explore the recent advances in the design of antimalarial drugs to target Plasmodium NMT.
期刊介绍：
Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.
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