Photopolymerization of Chlorpromazine-Loaded Gelatin Methacryloyl Hydrogels: Characterization and Antimicrobial Applications.

IF 5 3区 化学 Q1 POLYMER SCIENCE
Gels Pub Date : 2024-09-30 DOI:10.3390/gels10100632
Tatiana Tozar, Simona Nistorescu, Gratiela Gradisteanu Pircalabioru, Mihai Boni, Angela Staicu
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Abstract

This study investigates the synthesis, characterization, and antimicrobial properties of hydrogels synthesized through the UV-pulsed laser photopolymerization of a polymer-photoinitiator-chlorpromazine mixture. Chlorpromazine was used for its known enhanced antimicrobial properties when exposed to UV laser radiation. The hydrogel was formed from a mixture containing 0.05% Irgacure 2959, 10% gelatin methacryloyl, and various concentrations of chlorpromazine (1, 2, and 4 mg/mL). Laser-induced fluorescence spectroscopy was employed to monitor the photoinduced changes of chlorpromazine and Irgacure 2959 during hydrogel formation, providing insight into the photodegradation dynamics. FTIR spectroscopy confirmed the incorporation of irradiated chlorpromazine within the hydrogel matrix, while the release profiles of chlorpromazine showed sustained release only in hydrogels containing 1 mg/mL of CPZ. The hydrogel showed significant antimicrobial activity against MRSA bacteria when compared to that of penicillin. These findings highlight the potential of CPZ loaded during the photopolymerization process into hydrogels as effective antimicrobial agents with sustained release properties, making them suitable for combating resistant bacterial strains.

氯丙嗪负载明胶甲基丙烯酰水凝胶的光聚合:表征与抗菌应用。
本研究探讨了通过紫外脉冲激光光聚合聚合物-光引发剂-氯丙嗪混合物合成的水凝胶的合成、表征和抗菌特性。使用氯丙嗪是因为它在紫外激光辐射下具有已知的增强抗菌特性。水凝胶是由含有 0.05% Irgacure 2959、10% 明胶甲基丙烯酰和不同浓度的氯丙嗪(1、2 和 4 mg/mL)的混合物形成的。在水凝胶形成过程中,采用激光诱导荧光光谱监测氯丙嗪和 Irgacure 2959 的光诱导变化,从而深入了解光降解动态。傅立叶变换红外光谱证实了辐照后的氯丙嗪融入了水凝胶基质,而氯丙嗪的释放曲线显示只有在含有 1 毫克/毫升 CPZ 的水凝胶中才会持续释放。与青霉素相比,水凝胶对 MRSA 细菌具有显著的抗菌活性。这些发现凸显了在光聚合过程中将 CPZ 添加到水凝胶中作为具有持续释放特性的有效抗菌剂的潜力,使其适用于对抗耐药细菌菌株。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gels
Gels POLYMER SCIENCE-
CiteScore
4.70
自引率
19.60%
发文量
707
审稿时长
11 weeks
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