Hydrogel-Based Vascularized Organ Tissue Engineering: A Systematized Review on Abdominal Organs.

IF 5 3区化学 Q1 POLYMER SCIENCE

Gels Pub Date : 2024-10-12 DOI:10.3390/gels10100653

Filippos F Karageorgos, Maria Alexiou, Georgios Tsoulfas, Aleck H Alexopoulos

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引用次数: 0

Abstract

Background: Biomedical engineering, especially tissue engineering, is trying to provide an alternative solution to generate functional organs/tissues for use in various applications. These include beyond the final goal of transplantation, disease modeling and drug discovery as well. The aim of this study is to comprehensively review the existing literature on hydrogel-based vascularized organ (i.e., liver, pancreas, kidneys, intestine, stomach and spleen) tissue engineering of the abdominal organs.

Methods: A comprehensive literature search was conducted on the Scopus database (latest search 1 September 2024). The research studies including hydrogel-based vascularized organ tissue engineering in the organs examined here were eligible for the review.

Results: Herein, 18 studies were included. Specifically, 10 studies included the liver or hepatic tissue, 5 studies included the pancreas or pancreatic islet tissue, 3 studies included the kidney or renal tissue, 1 study included the intestine or intestinal or bowel tissue, 1 study included the stomach or gastric tissue, and 0 studies included spleen tissue.

Conclusion: Hydrogels are biocompatible materials with ideal characteristics for use as scaffolds. Even though organ tissue engineering is a rapidly growing field, there are still many obstacles to overcome to create a fully functional and long-lasting organ.

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基于水凝胶的血管化器官组织工程：腹部器官系统化综述。

背景：生物医学工程，尤其是组织工程，正试图提供一种替代解决方案，生成功能性器官/组织，用于各种应用。这些应用不仅包括移植、疾病建模和药物发现等最终目标。本研究旨在全面综述有关基于水凝胶的腹部器官（即肝脏、胰腺、肾脏、肠道、胃和脾脏）血管化组织工程的现有文献：在 Scopus 数据库中进行了全面的文献检索（最新检索日期为 2024 年 9 月 1 日）。结果：共纳入 18 项研究：结果：共纳入 18 项研究。具体而言，10 项研究包括肝脏或肝组织，5 项研究包括胰腺或胰岛组织，3 项研究包括肾脏或肾组织，1 项研究包括肠道或肠道组织，1 项研究包括胃或胃组织，0 项研究包括脾脏组织：结论：水凝胶是一种生物相容性材料，具有用作支架的理想特性。尽管器官组织工程是一个快速发展的领域，但要制造出功能齐全、使用寿命长的器官，仍有许多障碍需要克服。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gels POLYMER SCIENCE-

CiteScore

4.70

自引率

19.60%

发文量

707

审稿时长

11 weeks

期刊介绍： The journal Gels (ISSN 2310-2861) is an international, open access journal on physical (supramolecular) and chemical gel-based materials. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the maximum length of the papers, and full experimental details must be provided so that the results can be reproduced. Short communications, full research papers and review papers are accepted formats for the preparation of the manuscripts. Gels aims to serve as a reference journal with a focus on gel materials for researchers working in both academia and industry. Therefore, papers demonstrating practical applications of these materials are particularly welcome. Occasionally, invited contributions (i.e., original research and review articles) on emerging issues and high-tech applications of gels are published as special issues.