Gel-Based Suspension Medium Used in 3D Bioprinting for Constructing Tissue/Organ Analogs.

IF 5 3区 化学 Q1 POLYMER SCIENCE
Gels Pub Date : 2024-10-10 DOI:10.3390/gels10100644
Yang Luo, Rong Xu, Zeming Hu, Renhao Ni, Tong Zhu, Hua Zhang, Yabin Zhu
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引用次数: 0

Abstract

Constructing tissue/organ analogs with natural structures and cell types in vitro offers a valuable strategy for the in situ repair of damaged tissues/organs. Three-dimensional (3D) bioprinting is a flexible method for fabricating these analogs. However, extrusion-based 3D bioprinting faces the challenge of balancing the use of soft bioinks with the need for high-fidelity geometric shapes. To address these challenges, recent advancements have introduced various suspension mediums based on gelatin, agarose, and gellan gum microgels. The emergence of these gel-based suspension mediums has significantly advanced the fabrication of tissue/organ constructs using 3D bioprinting. They effectively stabilize and support soft bioinks, enabling the formation of complex spatial geometries. Moreover, they provide a stable, cell-friendly environment that maximizes cell viability during the printing process. This minireview will summarize the properties, preparation methods, and potential applications of gel-based suspension mediums in constructing tissue/organ analogs, while also addressing current challenges and providing an outlook on the future of 3D bioprinting.

三维生物打印中用于构建组织/器官模拟的凝胶悬浮介质。
在体外构建具有天然结构和细胞类型的组织/器官类似物为原位修复受损组织/器官提供了一种宝贵的策略。三维(3D)生物打印是制造这些类似物的一种灵活方法。然而,基于挤压的三维生物打印面临着如何在使用软性生物墨水与需要高保真几何形状之间取得平衡的挑战。为了应对这些挑战,最近的研究进展引入了各种基于明胶、琼脂糖和结冷胶微凝胶的悬浮介质。这些基于凝胶的悬浮介质的出现极大地推动了使用三维生物打印技术制造组织/器官构建体的进程。它们能有效地稳定和支持软生物沉淀物,从而形成复杂的空间几何形状。此外,它们还能提供稳定、对细胞友好的环境,在打印过程中最大限度地提高细胞活力。本微型综述将总结凝胶型悬浮介质在构建组织/器官类似物方面的特性、制备方法和潜在应用,同时还将探讨当前面临的挑战,并对三维生物打印的未来进行展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gels
Gels POLYMER SCIENCE-
CiteScore
4.70
自引率
19.60%
发文量
707
审稿时长
11 weeks
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