Ultrasensitive and highly selective Co²⁺ detection based on the chiral optical activities of L-glutathione-modified gold nanoclusters.

IF 3.8 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Frontiers in Chemistry Pub Date : 2024-10-09 eCollection Date: 2024-01-01 DOI:10.3389/fchem.2024.1478021

Qi Ding, Fang Wang, Weimin Yang, Xinhe Xing, Hengwei Lin, Liguang Xu, Si Li

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Abstract

Developing highly sensitive and selective detection methods is crucial for environmental and healthcare monitoring. In this study, the chiral and fluorescent signals of L-glutathione-modified gold nanoclusters (L-GSH-Au NCs) were discovered to be responsive to Co²⁺, which displayed linear correlations with the concentration changes of Co²⁺. Notably, the chiral signal was more sensitive than the FL signal, whose limit of detection (LOD) was calculated to be 0.37 μM and 3.93 times lower than the LOD obtained with fluorescent signals. Moreover, the chiral signals exhibited unexpectedly high selectivity towards Co²⁺, effectively avoiding interference from other metal ions and biomolecules. Furthermore, the concentrations of Co²⁺ in various samples, such as Taihu water, tap water, bottled water, and animal serum, were accurately quantified using the chiral signals of L-GSH-Au NCs without complex pretreatment, with recoveries ranging between 95.64% and 103.22%. This study not only provides an innovative approach for Co²⁺ detection but also highlights the detection capabilities of chiral signals in complex environments.

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基于 L-谷胱甘肽修饰金纳米团簇手性光学活性的超灵敏、高选择性 Co2+ 检测。

开发高灵敏度和高选择性的检测方法对于环境和医疗监测至关重要。本研究发现，L-谷胱甘肽修饰金纳米团簇（L-GSH-Au NCs）的手性信号和荧光信号对 Co2+ 具有响应性，与 Co2+ 的浓度变化呈线性相关。值得注意的是，手性信号比荧光信号更灵敏，其检测限（LOD）为 0.37 μM，比荧光信号的检测限低 3.93 倍。此外，手性信号对 Co2+ 的选择性出乎意料地高，有效地避免了其他金属离子和生物大分子的干扰。此外，利用 L-GSH-Au NCs 的手性信号，无需复合物预处理，即可准确定量分析太湖水、自来水、瓶装水和动物血清等各种样品中的 Co2+浓度，回收率在 95.64% 至 103.22% 之间。这项研究不仅为 Co2+ 的检测提供了一种创新方法，而且凸显了手性信号在复杂环境中的检测能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Chemistry Chemistry-General Chemistry

CiteScore

8.50

自引率

3.60%

发文量

1540

审稿时长

12 weeks

期刊介绍： Frontiers in Chemistry is a high visiblity and quality journal, publishing rigorously peer-reviewed research across the chemical sciences. Field Chief Editor Steve Suib at the University of Connecticut is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to academics, industry leaders and the public worldwide. Chemistry is a branch of science that is linked to all other main fields of research. The omnipresence of Chemistry is apparent in our everyday lives from the electronic devices that we all use to communicate, to foods we eat, to our health and well-being, to the different forms of energy that we use. While there are many subtopics and specialties of Chemistry, the fundamental link in all these areas is how atoms, ions, and molecules come together and come apart in what some have come to call the “dance of life”. All specialty sections of Frontiers in Chemistry are open-access with the goal of publishing outstanding research publications, review articles, commentaries, and ideas about various aspects of Chemistry. The past forms of publication often have specific subdisciplines, most commonly of analytical, inorganic, organic and physical chemistries, but these days those lines and boxes are quite blurry and the silos of those disciplines appear to be eroding. Chemistry is important to both fundamental and applied areas of research and manufacturing, and indeed the outlines of academic versus industrial research are also often artificial. Collaborative research across all specialty areas of Chemistry is highly encouraged and supported as we move forward. These are exciting times and the field of Chemistry is an important and significant contributor to our collective knowledge.