Post kidney transplant hematologic abnormalities and association of post-transplant anemia with graft function.

Q2 Pharmacology, Toxicology and Pharmaceutics

F1000Research Pub Date : 2024-09-26 eCollection Date: 2024-01-01 DOI:10.12688/f1000research.144124.2

Sindhura Lakshmi Koulmane Laxminarayana, Shreya Jayaram, Shilna Muttickal Swaminathan, Ravindra Prabhu Attur, Dharshan Rangaswamy, Indu Ramachandra Rao, Mohan V Bhojaraja, Srinivas Vinayak Shenoy, Shankar Prasad Nagaraju

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Abstract

Background: Haematological abnormalities following renal transplantation are frequently observed and have a significant effect on survival and graft outcomes. The pattern of haematological abnormalities varies globally. Few studies have been conducted in Asian countries. We aimed to evaluate the patterns of haematological abnormalities in post-transplant recipients in our center during the first year after post-renal transplant and the association of post-transplant anemia with graft function.

Methods: This single-center retrospective study was conducted on renal transplantation recipients between 2014 and 2019. The study included all patients who received kidney transplants from live/cadaveric donors and had follow-up data collected up to 12 months after the transplant. The outcome studied was the prevalence of haematological abnormalities and the association between post-transplant anemia (PTA) and graft function in post-transplant recipients.

Results: A total of 106 renal transplant recipients were included in the study. The prevalence of PTA was 98% in the first week, 75% at one month, 35% at three months, 32% at six months, and 27% at 12 months. The other cytopenia cases were leukopenia (43.4%), thrombocytopenia (33.2%), and pancytopenia (15.1%). Post-transplant erythrocytosis was observed in 17.9% of patients. 18 patients with severe PTA in the first week of transplant had significant allograft dysfunction (p=0.04). Patients with and without PTA had similar graft functions at six and 12 months (p=0.50).

Conclusions: Haematological abnormalities are common in renal transplant recipients. PTA is highly prevalent during the first week and improves over time. Other haematological abnormalities observed were leukopenia, thrombocytopenia, pancytopenia, and post-transplant erythrocytosis. Leucopenia was primarily drug-induced, and thrombocytopenia and pancytopenia were frequently caused by infections in our cohort. Additionally, severe PTA was significantly associated with graft dysfunction in the first week post-transplant, whereas similar graft function was observed at 6 and 12 months post-transplant, irrespective of the presence or absence of PTA.

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肾移植后血液学异常以及移植后贫血与移植功能的关系。

背景：肾移植术后经常会出现血液学异常，对存活率和移植结果有很大影响。全球血液学异常的模式各不相同。在亚洲国家进行的研究很少。我们旨在评估本中心肾移植术后受者在术后第一年的血液学异常模式，以及移植后贫血与移植物功能的关系：这项单中心回顾性研究针对2014年至2019年期间的肾移植受者。研究纳入了所有接受活体/尸体捐献者肾移植的患者，并收集了移植后 12 个月内的随访数据。研究结果为移植后受者血液学异常的发生率以及移植后贫血（PTA）与移植功能之间的关联：研究共纳入了 106 名肾移植受者。第一周的 PTA 患病率为 98%，一个月时为 75%，三个月时为 35%，六个月时为 32%，12 个月时为 27%。其他细胞减少病例包括白细胞减少症（43.4%）、血小板减少症（33.2%）和全血细胞减少症（15.1%）。17.9%的患者在移植后出现红细胞增多症。18名在移植第一周出现严重PTA的患者出现了明显的同种异体移植功能障碍（P=0.04）。有PTA和没有PTA的患者在6个月和12个月时的移植物功能相似（P=0.50）：结论：血液学异常在肾移植受者中很常见。结论：血液异常在肾移植受者中很常见，PTA 在第一周很常见，随着时间的推移会有所改善。观察到的其他血液学异常包括白细胞减少症、血小板减少症、全血细胞减少症和移植后红细胞增多症。白细胞减少主要是由药物引起的，而血小板减少和全血细胞减少则经常是由感染引起的。此外，严重的 PTA 与移植后第一周的移植物功能障碍显著相关，而无论是否存在 PTA，移植后 6 个月和 12 个月的移植物功能相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

F1000Research Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

5.00

自引率

0.00%

发文量

1646

审稿时长

1 weeks

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