Attenuated neutralization, maintained specificity: Humoral response to SARS-CoV-2 booster in kidney allograft recipients

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2024-10-16 DOI:10.1016/j.diagmicrobio.2024.116550

Martina Fialova , Eva Cecrdlova , Ivan Zahradka , Vojtech Petr , Filip Hruby , Istvan Modos , Ondrej Viklicky , Ilja Striz

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引用次数: 0

Abstract

Despite the lower virulence of current SARS-CoV-2 variants and high rates of vaccinated and previously infected subjects, COVID-19 remains a persistent threat in kidney transplant recipients (KTRs). This study evaluated the parameters of anti-SARS-CoV-2 antibody production in 120 KTRs. The production of neutralizing antibodies in KTRs, following booster vaccination with the mRNA vaccine BNT162b2, was significantly decreased and their decline was faster than in healthy subjects. Factors predisposing to the downregulation of anti-SARS-CoV-2 neutralizing antibodies included age, lower estimated glomerular filtration rate, and a full dose of mycophenolate mofetil. Neutralizing antibodies correlated with those targeting the SARS-CoV-2 receptor binding domain (RBD), SARS-CoV-2 Spike trimmer, total SARS-CoV-2 S1 protein, as well as with antibodies to the deadly SARS-CoV-1 virus. No cross-reactivity was found with antibodies against seasonal coronaviruses. KTRs exhibited lower postvaccination production of neutralizing antibodies against SARS-CoV-2; however, the specificity of their humoral response did not differ compared to healthy subjects.

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中和减弱，特异性保持：肾移植受者对 SARS-CoV-2 强化剂的体液反应。

尽管目前的 SARS-CoV-2 变体毒力较低，而且接种疫苗的受试者和以前感染过的受试者比例较高，但 COVID-19 仍是肾移植受者（KTR）的一个长期威胁。这项研究评估了 120 名 KTR 中抗 SARS-CoV-2 抗体产生的参数。KTR在接种mRNA疫苗BNT162b2后，中和抗体的产生量明显下降，且下降速度快于健康受试者。导致抗SARS-CoV-2中和抗体下调的因素包括年龄、较低的估计肾小球滤过率和全剂量的霉酚酸酯。中和抗体与针对SARS-CoV-2受体结合域（RBD）、SARS-CoV-2穗状修饰体、SARS-CoV-2 S1总蛋白以及致命的SARS-CoV-1病毒的抗体相关。与季节性冠状病毒抗体没有交叉反应。KTR 接种后产生的针对 SARS-CoV-2 的中和抗体较低；但与健康人相比，其体液反应的特异性并无差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.