Exosomes for Treating Hair Loss: A Review of Clinical Studies.

IF 2.5 3区医学 Q2 DERMATOLOGY

Dermatologic Surgery Pub Date : 2024-10-24 DOI:10.1097/DSS.0000000000004480

Dawn Queen, Marc R Avram

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引用次数: 0

Abstract

Background: The regenerative properties of exosomes make them especially appealing to treat skin and hair diseases. Preclinical studies suggest that exosomes may fuel hair growth by stimulating dermal papilla cells, activating hair follicle stem cells, and promoting angiogenesis. However, very limited data are available on the safety and efficacy of exosome use in human subjects.

Objective: To review the published literature on exosome use in human subjects with a focus on safety and the challenges facing clinical implementation in the treatment of androgenetic and nonscarring alopecias.

Materials and methods: A review was conducted of PubMed, EMBASE, and Cochrane databases and included 48 studies. Twenty-five studies were clinical trials, 14 case reports, 4 case series, 1 retrospective review, and 4 conference abstracts.

Results: Nine clinical studies were found relevant to alopecia. One hundred twenty-five patients received an exosome treatment for hair loss. Side effects were rare. However, in the broader field of dermatology, at least 10 serious adverse events have been reported.

Conclusion: Although exosomes have many promising therapeutic applications, there is demand for larger well-designed clinical trials with extended follow-up periods to prove efficacy and a need for consistent manufacturing standards and regulatory oversight to ensure product safety.

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用于治疗脱发的外泌体：临床研究综述。

背景：外泌体的再生特性使其在治疗皮肤和毛发疾病方面特别具有吸引力。临床前研究表明，外泌体可通过刺激真皮乳头细胞、激活毛囊干细胞和促进血管生成来促进毛发生长。然而，关于外泌体用于人体的安全性和有效性的数据非常有限：回顾已发表的关于外泌体用于人体的文献，重点关注安全性以及临床应用于治疗雄激素性和非瘢痕性脱发所面临的挑战：对 PubMed、EMBASE 和 Cochrane 数据库进行了综述，共纳入 48 项研究。其中 25 篇为临床试验，14 篇为病例报告，4 篇为系列病例，1 篇为回顾性综述，4 篇为会议摘要：结果：共发现 9 项与脱发相关的临床研究。125名脱发患者接受了外泌体治疗。副作用非常罕见。然而，在更广泛的皮肤科领域，至少有10起严重不良事件的报道：尽管外泌体有很多有前景的治疗应用，但仍需要更大规模、设计合理、随访时间更长的临床试验来证明其疗效，同时还需要一致的生产标准和监管监督来确保产品安全。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Surgery 医学-皮肤病学

CiteScore

3.10

自引率

16.70%

发文量

547

期刊介绍： Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including: -Ambulatory phlebectomy- Blepharoplasty- Body contouring- Chemical peels- Cryosurgery- Curettage and desiccation- Dermabrasion- Excision and closure- Flap Surgery- Grafting- Hair restoration surgery- Injectable neuromodulators- Laser surgery- Liposuction- Microdermabrasion- Microlipoinjection- Micropigmentation- Mohs micrographic surgery- Nail surgery- Phlebology- Sclerotherapy- Skin cancer surgery- Skin resurfacing- Soft-tissue fillers. Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.