Intermittent Fasting and Fasting-mimicking Diet: Promising Strategies in Cancer Management.

IF 3.5 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Chuanqiang Zhang, Fengqing Fu, Xingchao Zhu, Xiangyu Ni, Sijia Yue, Hongya Wu, Tongguo Shi
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引用次数: 0

Abstract

In the current review, we aim to elucidate the advancements concerning the roles and fundamental mechanisms of intermittent fasting (IF) and fasting-mimicking diet (FMD) in cancers. As a dietary intervention,IF and FMD potentially impede tumor growth by modulating multiple signaling pathways, such as AKT, Nrf2, and AMPK pathways.Moreover, IF and FMD have been reported to be associated with the tumor immune response by regulating various immune cells including tumor-associated macrophages (TAMs), monocytic myeloid-derived suppressor cells (MDSCs), T cells, and B cells.Additionally, IF and FMD can enhance the efficacy and tolerability of therapy, concurrently reducing therapy-induced side effects. Furthermore, several clinical trials have underscored the safety, feasibility, and positive impact on the quality of life associated with IF and FMD, thereby augmenting the effectiveness of conventional anti-- tumor therapies while ameliorating treatment-related side effects. This review provides a comprehensive synthesis of findings and elucidates the underlying mechanisms of IF and FMD in cancer progression and therapy.

间歇性禁食和禁食模拟饮食:治疗癌症的有效策略
在本综述中,我们旨在阐明有关间歇性禁食(IF)和禁食模拟饮食(FMD)在癌症中的作用和基本机制的研究进展。作为一种饮食干预措施,间歇性禁食和模拟禁食可通过调节多种信号通路(如 AKT、Nrf2 和 AMPK 通路)来抑制肿瘤生长。此外,有报道称 IF 和 FMD 与肿瘤免疫反应有关,可调节各种免疫细胞,包括肿瘤相关巨噬细胞(TAMs)、单核细胞髓源性抑制细胞(MDSCs)、T 细胞和 B 细胞。此外,一些临床试验强调了 IF 和 FMD 的安全性、可行性以及对生活质量的积极影响,从而增强了传统抗肿瘤疗法的有效性,同时改善了与治疗相关的副作用。本综述全面综述了相关研究结果,并阐明了 IF 和 FMD 在癌症进展和治疗中的潜在机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current medicinal chemistry
Current medicinal chemistry 医学-生化与分子生物学
CiteScore
8.60
自引率
2.40%
发文量
468
审稿时长
3 months
期刊介绍: Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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