Distribution Of Microrna Counts Across Human Chromosomes.

IF 3.5 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current medicinal chemistry Pub Date : 2024-10-24 DOI:10.2174/0109298673341375241009105556

Hsiuying Wang

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引用次数: 0

Abstract

Introduction: microRNAs (miRNAs) are a class of non-coding RNAs that play important roles in gene regulation. miRNAs are transcribed from DNA sequences into primary miRNAs and then processed into precursor miRNAs and mature miRNAs. miRNA gene counts in chromosomes for different species have been studied.

Method: Certain chromosomes have higher numbers of miRNA genes in all species, such as the X chromosome, while the Y chromosome has the fewest or no miRNA genes. miRNA counts in different chromosomes might have a positive correlation with coding gene counts in many species. In this study, a regression model was used to find the relationship between the miRNA count and the coding gene count across human chromosomes, and miRNA counts for 23 human chromosomes were predicted based on this regression model. In addition, the chromosome locations for the miRNA biomarkers of major depression, diabetes, Parkinson's disease, and COVID-19 are discussed.

Results: The results reveal that miRNA biomarkers of these diseases are located in various chromosomes. The dispersion of miRNA locations across different chromosomes might explain the complication of the pathology of these diseases. Moreover, diabetes and COVID-19 have the largest number of miRNA biomarkers from Chromosome X.

Conclusion: As Chromosome X is a sex chromosome, this phenomenon may explain the gender difference in the prevalence or severity of diabetes and COVID-19. The significant gender difference in the prevalence or severity of diabetes and COVID-19 might be due to the regulation function of their miRNA biomarkers from Chromosome X.

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小核糖体数量在人类染色体上的分布

导读：miRNA（miRNA）是一类非编码 RNA，在基因调控中发挥重要作用。miRNA 从 DNA 序列转录成初级 miRNA，然后加工成前体 miRNA 和成熟 miRNA：在所有物种中，某些染色体上的 miRNA 基因数量较多，如 X 染色体，而 Y 染色体上的 miRNA 基因数量最少或没有。本研究采用回归模型来寻找人类各染色体的 miRNA 数量与编码基因数量之间的关系，并根据该回归模型预测了 23 条人类染色体的 miRNA 数量。此外，还讨论了重度抑郁症、糖尿病、帕金森病和 COVID-19 的 miRNA 生物标志物的染色体位置：结果显示，这些疾病的 miRNA 生物标志物位于不同的染色体上。结果：研究结果表明，这些疾病的 miRNA 生物标志物分布在不同的染色体上，miRNA 在不同染色体上的位置分散可能是这些疾病病理复杂化的原因。此外，糖尿病和 COVID-19 中来自 X 染色体的 miRNA 生物标记物数量最多：结论：由于 X 染色体是性染色体，这一现象可能解释了糖尿病和 COVID-19 在患病率或严重程度上的性别差异。糖尿病和 COVID-19 在患病率或严重程度上存在明显的性别差异，可能与来自 X 染色体的 miRNA 生物标志物的调控功能有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current medicinal chemistry 医学-生化与分子生物学

CiteScore

8.60

自引率

2.40%

发文量

468

审稿时长

3 months

期刊介绍： Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.