Azelaic Acid: Mechanisms of Action and Clinical Applications.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-10-22 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S485237

Xiaoyue Feng, Jianli Shang, Zhengping Gu, Junhua Gong, Yong Chen, Youting Liu

引用次数: 0

Abstract

AZA is a non-phenolic, saturated dicarboxylic acid with nine carbon atoms, naturally produced by the yeast Malassezia. It has diverse physiological activities, including antibacterial, anti-keratinizing, antimelanogenic, antioxidant and anti-inflammatory effects. AZA is widely used in dermatology and is FDA-approved for treating papulopustular rosacea. It also shows significant efficacy in acne vulgaris and melasma. This review summarizes the mechanisms of action and clinical applications of AZA, aiming to provide theoretical support for its clinical and cosmetic use and to facilitate further research.

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壬二酸：作用机制和临床应用。

AZA 是一种非酚类饱和二羧酸，有 9 个碳原子，由马拉色菌酵母天然产生。它具有多种生理活性，包括抗菌、抗角化、抗黑色素生成、抗氧化和抗炎作用。AZA 被广泛应用于皮肤科，并被 FDA 批准用于治疗丘疹脓疱型红斑痤疮。它对寻常痤疮和黄褐斑也有明显疗效。本综述总结了 AZA 的作用机制和临床应用，旨在为其临床和美容用途提供理论支持，并促进进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.