Hypothalamic regulation of hippocampal CA1 interneurons by the supramammillary nucleus.

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2024-10-23 DOI:10.1016/j.celrep.2024.114898

Yu-Qiu Jiang, Daniel K Lee, Wanyi Guo, Minghua Li, Qian Sun

{"title":"Hypothalamic regulation of hippocampal CA1 interneurons by the supramammillary nucleus.","authors":"Yu-Qiu Jiang, Daniel K Lee, Wanyi Guo, Minghua Li, Qian Sun","doi":"10.1016/j.celrep.2024.114898","DOIUrl":null,"url":null,"abstract":"The hypothalamic supramammillary nucleus (SuM) projects heavily to the hippocampus to regulate hippocampal activity and plasticity. Although the projections from the SuM to the dentate gyrus (DG) and CA2 have been extensively studied, whether the SuM projects to CA1, the main hippocampal output region, is unclear. Here, we report a glutamatergic pathway from the SuM that selectively excites CA1 interneurons in the border between the stratum radiatum (SR) and the stratum lacunosum-moleculare (SLM). We find that the SuM projects selectively to a narrow band in the CA1 SR/SLM and monosynaptically excites SR/SLM interneurons, including vasoactive intestinal peptide-expressing (VIP+) and neuron-derived neurotrophic factor-expressing (NDNF+) cells, but completely avoids making monosynaptic contacts with CA1 pyramidal neurons (PNs) or parvalbumin-expressing (PV+) or somatostatin-expressing (SOM+) cells. Moreover, SuM activation drives spikes in most SR/SLM interneurons to suppress CA1 PN excitability. Taken together, our findings reveal that the SuM can directly regulate hippocampal output region CA1, bypassing CA2, CA3, and the DG.","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":"43 11","pages":"114898"},"PeriodicalIF":7.5000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell reports","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.celrep.2024.114898","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The hypothalamic supramammillary nucleus (SuM) projects heavily to the hippocampus to regulate hippocampal activity and plasticity. Although the projections from the SuM to the dentate gyrus (DG) and CA2 have been extensively studied, whether the SuM projects to CA1, the main hippocampal output region, is unclear. Here, we report a glutamatergic pathway from the SuM that selectively excites CA1 interneurons in the border between the stratum radiatum (SR) and the stratum lacunosum-moleculare (SLM). We find that the SuM projects selectively to a narrow band in the CA1 SR/SLM and monosynaptically excites SR/SLM interneurons, including vasoactive intestinal peptide-expressing (VIP⁺) and neuron-derived neurotrophic factor-expressing (NDNF⁺) cells, but completely avoids making monosynaptic contacts with CA1 pyramidal neurons (PNs) or parvalbumin-expressing (PV⁺) or somatostatin-expressing (SOM⁺) cells. Moreover, SuM activation drives spikes in most SR/SLM interneurons to suppress CA1 PN excitability. Taken together, our findings reveal that the SuM can directly regulate hippocampal output region CA1, bypassing CA2, CA3, and the DG.

查看原文本刊更多论文

下丘脑调节海马CA1中间神经元的上绒毛核

下丘脑绒毛上核（SuM）向海马大量投射，以调节海马的活动和可塑性。尽管人们已经广泛研究了SuM向齿状回（DG）和CA2的投射，但还不清楚SuM是否向海马的主要输出区CA1投射。在这里，我们报告了一条来自 SuM 的谷氨酸能通路，该通路选择性地兴奋位于放射层（SR）和透明带层（SLM）交界处的 CA1 中间神经元。我们发现，SuM选择性地投射到CA1 SR/SLM的一个狭窄带，单突触兴奋SR/SLM中间神经元，包括表达血管活性肠肽（VIP+）和神经元衍生神经营养因子（NDNF+）的细胞，但完全避免与CA1锥体神经元（PNs）或表达副阀素（PV+）或表达体节素（SOM+）的细胞进行单突触接触。此外，SuM 激活会驱动大多数 SR/SLM 中间神经元产生尖峰，从而抑制 CA1 PN 的兴奋性。综上所述，我们的研究结果表明，SuM 可以绕过 CA2、CA3 和 DG 直接调节海马输出区 CA1。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.