The Utilization of PRAME in the Diagnosis, Prognosis, and Treatment of Melanoma.

IF 5.1 2区 生物学 Q2 CELL BIOLOGY
Cells Pub Date : 2024-10-20 DOI:10.3390/cells13201740
Samuel L Blount, Xiaochen Liu, Jeffrey D McBride
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引用次数: 0

Abstract

Melanoma, a deadly form of skin cancer, has seen improved survival rates due to advances in diagnosis and treatment, yet the need for further improvement remains critical. Tumor-associated antigens, such as PRAME (Preferentially Expressed Antigen in Melanoma), offer promising avenues for enhanced diagnostic precision, prognostic assessment, and targeted immunotherapy. PRAME, a cancer testis antigen, is selectively expressed in various cancers, including melanoma, and plays a key role in promoting tumorigenesis through inhibition of retinoic acid signaling, epithelial-to-mesenchymal transition, and immune evasion. This review explores the diagnostic utility of PRAME in distinguishing melanoma from benign nevi, its prognostic value in aggressive melanoma subtypes, and its potential as a therapeutic target in cancer vaccines and adoptive T-cell therapies. While PRAME-targeted therapies face challenges such as tumor heterogeneity and immune suppression, ongoing research aims to overcome these barriers, offering hope for more effective melanoma treatments.

在黑色素瘤的诊断、预后和治疗中使用 PRAME。
黑色素瘤是一种致命的皮肤癌,由于诊断和治疗方面的进步,黑色素瘤患者的存活率有所提高,但仍亟需进一步改善。PRAME(黑色素瘤优先表达抗原)等肿瘤相关抗原为提高诊断精确度、预后评估和靶向免疫疗法提供了前景广阔的途径。PRAME是一种癌症睾丸抗原,在包括黑色素瘤在内的多种癌症中选择性表达,并通过抑制维甲酸信号传导、上皮细胞向间质转化和免疫逃避在促进肿瘤发生方面发挥着关键作用。本综述探讨了 PRAME 在区分黑色素瘤和良性痣方面的诊断作用、它在侵袭性黑色素瘤亚型中的预后价值,以及它作为癌症疫苗和免疫细胞疗法的治疗靶点的潜力。虽然PRAME靶向疗法面临着肿瘤异质性和免疫抑制等挑战,但正在进行的研究旨在克服这些障碍,为更有效的黑色素瘤治疗带来希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cells
Cells Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
9.90
自引率
5.00%
发文量
3472
审稿时长
16 days
期刊介绍: Cells (ISSN 2073-4409) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to cell biology, molecular biology and biophysics. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.
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