The Neural Correlations of Olfactory Associative Reward Memories in Drosophila.

IF 5.1 2区 生物学 Q2 CELL BIOLOGY
Cells Pub Date : 2024-10-17 DOI:10.3390/cells13201716
Yu-Chun Lin, Tony Wu, Chia-Lin Wu
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引用次数: 0

Abstract

Advancing treatment to resolve human cognitive disorders requires a comprehensive understanding of the molecular signaling pathways underlying learning and memory. While most organ systems evolved to maintain homeostasis, the brain developed the capacity to perceive and adapt to environmental stimuli through the continuous modification of interactions within a gene network functioning within a broader neural network. This distinctive characteristic enables significant neural plasticity, but complicates experimental investigations. A thorough examination of the mechanisms underlying behavioral plasticity must integrate multiple levels of biological organization, encompassing genetic pathways within individual neurons, interactions among neural networks providing feedback on gene expression, and observable phenotypic behaviors. Model organisms, such as Drosophila melanogaster, which possess more simple and manipulable nervous systems and genomes than mammals, facilitate such investigations. The evolutionary conservation of behavioral phenotypes and the associated genetics and neural systems indicates that insights gained from flies are pertinent to understanding human cognition. Rather than providing a comprehensive review of the entire field of Drosophila memory research, we focus on olfactory associative reward memories and their related neural circuitry in fly brains, with the objective of elucidating the underlying neural mechanisms, thereby advancing our understanding of brain mechanisms linked to cognitive systems.

果蝇嗅觉联想奖励记忆的神经相关性
要推进解决人类认知障碍的治疗,就必须全面了解学习和记忆的分子信号通路。大多数器官系统的进化都是为了维持体内平衡,而大脑则是通过不断改变在更广泛的神经网络中发挥作用的基因网络内的相互作用,发展出感知和适应环境刺激的能力。这一显著特点使神经具有很大的可塑性,但也使实验研究变得复杂。要彻底研究行为可塑性的内在机制,必须整合多个层次的生物组织,包括单个神经元内的遗传途径、提供基因表达反馈的神经网络之间的相互作用以及可观察到的表型行为。与哺乳动物相比,黑腹果蝇等模式生物的神经系统和基因组更简单、更易于操作,这为此类研究提供了便利。行为表型及相关遗传学和神经系统在进化过程中保持不变,这表明从果蝇身上获得的知识有助于理解人类的认知。我们没有对果蝇记忆研究的整个领域进行全面回顾,而是重点研究了果蝇大脑中的嗅觉联想奖赏记忆及其相关神经回路,目的是阐明其潜在的神经机制,从而推进我们对与认知系统相关的大脑机制的理解。
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来源期刊
Cells
Cells Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
9.90
自引率
5.00%
发文量
3472
审稿时长
16 days
期刊介绍: Cells (ISSN 2073-4409) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to cell biology, molecular biology and biophysics. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.
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