Early-Life Respiratory Syncytial Virus (RSV) Infection Triggers Immunological Changes in Gut-Associated Lymphoid Tissues in a Sex-Dependent Manner in Adulthood.

IF 5.1 2区 生物学 Q2 CELL BIOLOGY
Cells Pub Date : 2024-10-18 DOI:10.3390/cells13201728
Stella Liong, Felicia Liong, Mitra Mohsenipour, Elisa L Hill-Yardin, Mark A Miles, Stavros Selemidis
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引用次数: 0

Abstract

Severe respiratory syncytial virus (RSV) infection during early life has been linked to gut dysbiosis, which correlates with increased disease severity and a higher risk of developing asthma later in life. However, the impact of such early-life RSV infections on intestinal immunity in adulthood remains unclear. Herein, we show that RSV infection in 3-week-old mice induced persistent differential natural killer (NK) and T cell profiles within the lungs and gastrointestinal (GI) lymphoid tissues (GALT) in adulthood. Notably, male mice exhibited more pronounced RSV-induced changes in immune cell populations in both the lungs and GALT, while female mice displayed greater resilience. Importantly, early-life RSV infection was associated with the chronic downregulation of CD69-expressing T lymphocytes, particularly T regulatory cells in Peyer's patches, which could have a significant impact on T cell functionality and immune tolerance. We propose that RSV infection in early life is a trigger for the breakdown in immune tolerance at mucosal surfaces, with potential implications for airways allergic disease, food allergies, and other GI inflammatory diseases.

早期呼吸道合胞病毒(RSV)感染引发成年期肠道相关淋巴组织的免疫学变化与性别有关
早年的严重呼吸道合胞病毒(RSV)感染与肠道菌群失调有关,而肠道菌群失调与疾病严重程度的增加以及日后患哮喘的风险增加相关。然而,这种早期 RSV 感染对成年后肠道免疫的影响仍不清楚。在本文中,我们发现 3 周大的小鼠感染 RSV 后,成年后肺部和胃肠道淋巴组织(GALT)中的自然杀伤细胞(NK)和 T 细胞会出现持续性差异。值得注意的是,雄性小鼠肺部和胃肠道淋巴组织中由 RSV 诱导的免疫细胞群变化更为明显,而雌性小鼠则表现出更强的适应能力。重要的是,生命早期的 RSV 感染与表达 CD69 的 T 淋巴细胞(尤其是佩耶氏斑块中的 T 调节细胞)的慢性下调有关,这可能会对 T 细胞的功能和免疫耐受性产生重大影响。我们认为,早年的 RSV 感染是粘膜表面免疫耐受破坏的触发因素,对气道过敏性疾病、食物过敏和其他消化道炎症性疾病具有潜在的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cells
Cells Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
9.90
自引率
5.00%
发文量
3472
审稿时长
16 days
期刊介绍: Cells (ISSN 2073-4409) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to cell biology, molecular biology and biophysics. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.
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