Reconciliation of weak pairwise spike-train correlations and highly coherent local field potentials across space.

Abstract

Multi-electrode arrays covering several square millimeters of neural tissue provide simultaneous access to population signals such as extracellular potentials and spiking activity of one hundred or more individual neurons. The interpretation of the recorded data calls for multiscale computational models with corresponding spatial dimensions and signal predictions. Multi-layer spiking neuron network models of local cortical circuits covering about $1\,{\text{mm}^{2}}$ have been developed, integrating experimentally obtained neuron-type-specific connectivity data and reproducing features of observed in-vivo spiking statistics. Local field potentials can be computed from the simulated spiking activity. We here extend a local network and local field potential model to an area of $4\times 4\,{\text{mm}^{2}}$, preserving the neuron density and introducing distance-dependent connection probabilities and conduction delays. We find that the upscaling procedure preserves the overall spiking statistics of the original model and reproduces asynchronous irregular spiking across populations and weak pairwise spike-train correlations in agreement with experimental recordings from sensory cortex. Also compatible with experimental observations, the correlation of local field potential signals is strong and decays over a distance of several hundred micrometers. Enhanced spatial coherence in the low-gamma band around $50\,\text{Hz}$ may explain the recent report of an apparent band-pass filter effect in the spatial reach of the local field potential.