Unintended placement of intraocular lens haptics in the sulcus and its association with posterior capsular opacification in pseudophakic post-mortem eyes.

IF 3.3 4区 医学 Q1 OPHTHALMOLOGY
Emmanuel Issa Nassrallah, Raphaëlle Denis, Georges Nassrallah, Ana Beatriz Dias, Hiroaki Ito, Christina Mastromonaco, Nabil Saheb, Miguel N Burnier
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Abstract

Objective: To assess the prevalence of unintended placement of intraocular lens (IOL) haptics in the sulcus and its association with posterior capsular opacification (PCO).

Design: Cross-sectional study.

Participants: 428 post-mortem pseudophakic human eyes.

Methods: Eyes were obtained from the Lions Gift of Sight and imaged in Miyake-Apple view (MAV). IOL haptic placement (bag-bag, bag-sulcus, sulcus-sulcus) was determined from the MAV images. IOL-capsular bag complexes were extracted and analyzed via Automated Detector Opacification Software to quantify PCO and Soemmering's Ring (SR). SR distribution was categorized as focal, diffuse, or none. Mean differences in PCO and SR between haptic groups were assessed via Welch's t-test. Odds ratios were used to compare the risk of SR distribution patterns between both haptic groups. Sex, clinical history (diabetes, smoking, hypertension, glaucoma, cancer, age-related macular degeneration [AMD], hypercholesterolemia, cardiovascular disease), and IOL model and specifications were collected.

Results: 20 eyes (4.67%) had unintended sulcus placement of haptics. Mean PCO (p = 0.0367) and SR (p = 0.0414) were significantly higher in sulcus eyes. Sulcus eyes were significantly more at risk of focal SR distribution (OR 8.715; p < 0.0001) and significantly less at risk of diffuse SR distribution (OR 0.168; p = .0007). Sulcus eyes had significantly higher frequencies of glaucoma (p < 0.0001) and AMD (p = 0.0023) on clinical history.

Conclusions: This study demonstrates that unintended sulcus placement of IOL haptics may be associated with an increased risk of PCO and SR formation. This study offers clinical signs of sulcus haptic placement that may prompt physicians to seek earlier appropriate intervention.

在假性瓣膜病死后眼球的沟槽中意外放置眼内晶状体触点及其与后囊不透明的关联。
摘要评估眼内晶状体(IOL)触针在沟内意外放置的发生率及其与后囊变性(PCO)的关系:设计:横断面研究:428只死后假性角膜翳人眼:方法:从 "狮子视力礼物"(Lions Gift of Sight)中获取眼球,并在三宅-苹果视图(MAV)下进行成像。根据 MAV 图像确定人工晶体的触觉位置(囊-囊、囊-沟、沟-沟)。通过自动检测不透明软件提取并分析人工晶体-囊袋复合体,以量化 PCO 和 Soemmering's Ring (SR)。SR 分布分为局灶性、弥漫性或无。触觉组之间 PCO 和 SR 的平均差异通过韦尔奇 t 检验进行评估。用比值比来比较两个触觉组之间 SR 分布模式的风险。收集了性别、临床病史(糖尿病、吸烟、高血压、青光眼、癌症、老年性黄斑变性[AMD]、高胆固醇血症、心血管疾病)、人工晶体型号和规格。沟眼的平均 PCO(p = 0.0367)和 SR(p = 0.0414)明显更高。沟眼发生局灶性 SR 分布的风险明显更高(OR 8.715;p < 0.0001),发生弥漫性 SR 分布的风险明显更低(OR 0.168;p = 0.0007)。根据临床病史,囊肿眼患青光眼(p < 0.0001)和老年性黄斑变性(p = 0.0023)的频率明显更高:本研究表明,在非预期的沟内放置人工晶体触点可能与 PCO 和 SR 形成的风险增加有关。本研究提供了人工晶体植入沟的临床表现,可促使医生尽早采取适当的干预措施。
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来源期刊
CiteScore
3.20
自引率
4.80%
发文量
223
审稿时长
38 days
期刊介绍: Official journal of the Canadian Ophthalmological Society. The Canadian Journal of Ophthalmology (CJO) is the official journal of the Canadian Ophthalmological Society and is committed to timely publication of original, peer-reviewed ophthalmology and vision science articles.
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