The development of the occurrence and metastasis of breast cancer by single-cell sequencing.

IF 5.3 2区医学 Q1 ONCOLOGY

Cancer Cell International Pub Date : 2024-10-26 DOI:10.1186/s12935-024-03531-x

Man Chen, Mengya Feng, Hai Lei, Dan Mo, Shengnan Ren, Dechun Yang

引用次数: 0

Abstract

Breast cancer is currently the most frequent malignant tumor and the leading cause of cancer death among women globally. Although the five-year survival rate for early breast cancer has risen to more than 90%, medication resistance persists in advanced breast cancer and some intractable breast cancer, resulting in a poor prognosis, a high recurrence rate, and a low survival rate. Single-cell sequencing (SCS) is the study of a single cell's gene structure and expression level differences in order to discover unusual molecular subgroups, disease development, and a variety of mechanisms. This review briefly discusses single-cell sequencing and its application, and lists the research on single-cell sequencing in the development and metastasis of breast cancer, in order to bring fresh ideas for the comprehensive treatment of breast cancer.

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通过单细胞测序研究乳腺癌的发生和转移发展。

乳腺癌是目前发病率最高的恶性肿瘤，也是全球女性癌症死亡的主要原因。虽然早期乳腺癌的五年生存率已上升到 90% 以上，但晚期乳腺癌和一些难治性乳腺癌仍存在耐药性，导致预后差、复发率高、生存率低。单细胞测序（SCS）是对单个细胞的基因结构和表达水平差异进行研究，以发现异常分子亚群、疾病发展和各种机制。本综述简要论述了单细胞测序及其应用，并列举了单细胞测序在乳腺癌发病和转移中的研究，以期为乳腺癌的综合治疗带来新思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell International ONCOLOGY-

CiteScore

10.90

自引率

1.70%

发文量

360

审稿时长

1 months

期刊介绍： Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.