Prospective comparative diagnostic performance of quantitative ultrasound parameters for the measurement of hepatic steatosis in a biopsy-proven MASLD cohort.
IF 1.8 4区 医学Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Kun Wang, Jingwen Bao, Minghui Wang, Yanjie Yu, Min Wang
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引用次数: 0
Abstract
Objectives: The aim of this study was to compare the diagnostic performance of attenuation imaging (ATI), shear wave elastography (SWE) and shear wave dispersion (SWD) for detecting and grading hepatic steatosis in patients with metabolic dysfunctionassociated steatotic liver disease (MASLD).
Methods: 66 patients with MASLD (mean age, 41 years ± 12; 36 men, 30 women) confirmed histopathologically and 34 healthy volunteers (mean age, 39 years ± 15; 18 men, 16 women) who were age/sex-matched were prospectively enrolled in this study. ATI, SWE and SWD examinations were performed. Fibrosis stage, necroinflammatory activity and steatosis grade were confirmed histopathologically. Steatosis was graded as follows: S0 (<5%); S1 (5-32%); S2 (33-66%) to S3 (>66%). We compared the diagnostic performance of ATI, SWE and SWD for detecting and grading hepatic steatosis.
Results: Both attenuation coefficient (AC) and SWD values were significantly different among the different hepatic steatosis, and both were correlated with hepatic steatosis. SWE could not distinguish hepatic steatosis. ATI had better diagnostic performance than SWD for detecting and grading hepatic steatosis. The area under the receiver operating characteristic (ROC) curve of ATI for detecting ≥ S1, ≥ S2, and = S3 were 0.917 (cut-off value of 0.69 dB/cm/MHz), 0.933 (cut-off value of 0.74 dB/cm/MHz), and 0.870 (cut-off value of 0.82 dB/cm/MHz), respectively. The area under the ROC curve of SWD value was 0.758 (cut-off value of 10.79 m/s/kHz), 0.685 (cut-off value of 12.64 m/s/kHz), and 0.722 (cut-off value of 13.24 m/s/kHz), respectively.
Conclusions: ATI technology is a reliable method for detecting and grading hepatic steatosis in patients with MASLD than SWE and SWD.
Advances in knowledge: We compared the diagnostic performance of ATI, SWE, SWD for detecting and grading hepatic steatosis in patients with MASLD in order to find the best diagnostic parameters.
期刊介绍：
BJR is the international research journal of the British Institute of Radiology and is the oldest scientific journal in the field of radiology and related sciences.
Dating back to 1896, BJR’s history is radiology’s history, and the journal has featured some landmark papers such as the first description of Computed Tomography "Computerized transverse axial tomography" by Godfrey Hounsfield in 1973. A valuable historical resource, the complete BJR archive has been digitized from 1896.
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