The effects of conjugated linoleic acid supplementation on cardiovascular risk factors in patients at risk of cardiovascular disease: A GRADE-assessed systematic review and dose-response meta-analysis.

IF 3 3区医学 Q2 NUTRITION & DIETETICS

British Journal of Nutrition Pub Date : 2024-10-23 DOI:10.1017/S0007114524001065

Maryam Esmaeilnejad, Niloufar Rasaei, Kian Goudarzi, Zahra Behrouz Dehkordi, Sina Dolatshahi, Hossein Salehi Omran, Niusha Amirani, Damoon Ashtary-Larky, Ghazaleh Shimi, Omid Asbaghi

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Abstract

The present systematic review and meta-analysis sought to evaluate the effects of conjugated linoleic acid (CLA) supplementation on cardiovascular risk factors in patients at risk of CVD. Relevant studies were obtained by searching the PubMed, SCOPUS and Web of Science databases (from inception to January 2023). Weighted mean differences (WMD) and 95% CI were pooled using a random-effects model. Heterogeneity, sensitivity analysis and publication bias were reported using standard methods. A pooled analysis of 14 randomised controlled trials (RCT) with 17 effect sizes revealed that CLA supplementation led to significant reductions in body weight (WMD: -0·72 kg, 95% CI: -1·11, -0·33, P < 0·001), BMI (WMD: -0·22 kg/m², 95% CI: -0·44, -0·00, P = 0·037) and body fat percentage (BFP) (WMD: -1·32 %, 95% CI: -2·24, -0·40, P = 0·005). However, there was no effect on lipid profile and blood pressure in comparison with the control group. In conclusion, CLA supplementation may yield a small but significant beneficial effect on anthropometric indices in patients at risk of CVD. Moreover, CLA seems not to have adverse effects on lipid profiles and blood pressure in patients at risk of CVD. It should be noted that the favourable effects of CLA supplementation on anthropometric variables were small and may not reach clinical importance.

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补充共轭亚油酸对心血管疾病高危人群心血管风险因素的影响：经过 GRADE 评估的系统综述和剂量反应荟萃分析。

本系统综述和荟萃分析旨在评估补充共轭亚油酸（CLA）对心血管疾病高危患者心血管风险因素的影响。相关研究是通过搜索 PubMed、SCOPUS 和 Web of Science 数据库（从开始到 2023 年 1 月）获得的。采用随机效应模型对加权平均差（WMD）和 95% CI 进行了汇总。采用标准方法报告异质性、敏感性分析和发表偏倚。对 14 项随机对照试验（RCT）和 17 个效应大小进行的汇总分析表明，补充 CLA 可显著降低体重（WMD：-0-72 kg，95% CI：-1-11，-0-33，P < 0-001）、体重指数（BMI）（WMD：-0-22 kg/m2，95% CI：-0-44，-0-00，P = 0-037）和体脂百分比（BFP）（WMD：-1-32 %，95% CI：-2-24，-0-40，P = 0-005）。不过，与对照组相比，对血脂和血压没有影响。总之，补充 CLA 可对心血管疾病高危患者的人体测量指数产生微小但显著的有益影响。此外，CLA 似乎不会对心血管疾病高危患者的血脂和血压产生不良影响。需要注意的是，补充 CLA 对人体测量变量的有利影响较小，可能不具有临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Nutrition 医学-营养学

CiteScore

6.60

自引率

5.60%

发文量

740

审稿时长

3 months

期刊介绍： British Journal of Nutrition is a leading international peer-reviewed journal covering research on human and clinical nutrition, animal nutrition and basic science as applied to nutrition. The Journal recognises the multidisciplinary nature of nutritional science and includes material from all of the specialities involved in nutrition research, including molecular and cell biology and nutritional genomics.