Quantification of white matter hyperintensities in type 1 diabetes and its relation to neuropathy and clinical characteristics

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2024-10-20 DOI:10.1016/j.brainres.2024.149288

Tine M. Hansen , Suganthiya S. Croosu , Shahram Kianimehr , Mimoza Gjela , Johan Røikjer , Yousef Yavarian , Carsten D. Mørch , Niels Ejskjaer , Jens B. Frøkjær

{"title":"Quantification of white matter hyperintensities in type 1 diabetes and its relation to neuropathy and clinical characteristics","authors":"Tine M. Hansen , Suganthiya S. Croosu , Shahram Kianimehr , Mimoza Gjela , Johan Røikjer , Yousef Yavarian , Carsten D. Mørch , Niels Ejskjaer , Jens B. Frøkjær","doi":"10.1016/j.brainres.2024.149288","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><div>The aims were to quantify periventricular and deep white matter hyperintensities (WMHs) in adults with type 1 diabetes with different neuropathic phenotypes and to correlate WMH measurements to explanatory factors in diabetes.</div></div><div><h3>Methods</h3><div>WMH measurements were obtained from brain magnetic resonance imaging of 56 adults with type 1 diabetes in subgroups including painful diabetic peripheral neuropathy (DPN), painless DPN, without DPN and 20 healthy controls using Fazekas scale and automatic segmentation analysis.</div></div><div><h3>Results</h3><div>No differences in Fazekas assessed WMHs were found (individuals with periventricular lesions: diabetes 66 % vs. controls 40 %, p = 0.063, deep lesions: diabetes 52 % vs. controls 50 %, p = 1.0). Using automatic detection, there were no significant differences in count of periventricular (p = 0.30) or deep (p = 0.31) WMHs. Higher periventricular lesion burden was present in diabetes compared with controls (0.21 % vs. 0.06 %, p = 0.048), which was associated with more severe DPN, increased age, decreased cognitive function, and reduced volumetric and metabolic brain measures (all p < 0.05).</div></div><div><h3>Conclusions</h3><div>Our findings indicate increased burden of periventricular WMHs in diabetes which were associated to DPN severity and measurements reflecting neurodegeneration. Deep WMHs, often considered as chronic ischemic, were not significantly different. Mechanisms reflecting neurodegeneration and accelerated brain aging could be an overlooked aspect of peripheral and central neuropathy.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1846 ","pages":"Article 149288"},"PeriodicalIF":2.7000,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0006899324005420","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Aims

The aims were to quantify periventricular and deep white matter hyperintensities (WMHs) in adults with type 1 diabetes with different neuropathic phenotypes and to correlate WMH measurements to explanatory factors in diabetes.

Methods

WMH measurements were obtained from brain magnetic resonance imaging of 56 adults with type 1 diabetes in subgroups including painful diabetic peripheral neuropathy (DPN), painless DPN, without DPN and 20 healthy controls using Fazekas scale and automatic segmentation analysis.

Results

No differences in Fazekas assessed WMHs were found (individuals with periventricular lesions: diabetes 66 % vs. controls 40 %, p = 0.063, deep lesions: diabetes 52 % vs. controls 50 %, p = 1.0). Using automatic detection, there were no significant differences in count of periventricular (p = 0.30) or deep (p = 0.31) WMHs. Higher periventricular lesion burden was present in diabetes compared with controls (0.21 % vs. 0.06 %, p = 0.048), which was associated with more severe DPN, increased age, decreased cognitive function, and reduced volumetric and metabolic brain measures (all p < 0.05).

Conclusions

Our findings indicate increased burden of periventricular WMHs in diabetes which were associated to DPN severity and measurements reflecting neurodegeneration. Deep WMHs, often considered as chronic ischemic, were not significantly different. Mechanisms reflecting neurodegeneration and accelerated brain aging could be an overlooked aspect of peripheral and central neuropathy.

查看原文本刊更多论文

1 型糖尿病患者白质高密度的量化及其与神经病变和临床特征的关系。

目的：旨在量化具有不同神经病理性表型的 1 型糖尿病成人患者的脑室周围和深部白质高密度（WMH），并将 WMH 测量值与糖尿病的解释因素相关联：采用法泽卡斯量表和自动分割分析法，对56名1型糖尿病成人患者的脑磁共振成像进行WMH测量，这些患者分为疼痛型糖尿病周围神经病变（DPN）、无痛型糖尿病周围神经病变、无DPN和20名健康对照组：结果：法泽卡斯评估的 WMHs 没有发现差异（室周病变：糖尿病患者 66% 对对照组 40%，P = 0.063；深部病变：糖尿病患者 52% 对对照组 50%，P = 1.0）。使用自动检测时，脑室周围（p = 0.30）或深部（p = 0.31）WMHs 的数量无明显差异。与对照组相比，糖尿病患者的脑室周围病变负荷更高（0.21 % vs. 0.06 %，p = 0.048），这与更严重的DPN、年龄增加、认知功能下降以及脑容量和代谢指标降低有关（所有p均为结论）：我们的研究结果表明，糖尿病患者脑室周围 WMHs 负担加重，这与 DPN 的严重程度和反映神经变性的指标有关。通常被认为是慢性缺血性的深部 WMHs 没有明显差异。反映神经变性和大脑加速衰老的机制可能是周围和中枢神经病变被忽视的一个方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.