[¹⁸F]NaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders.

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2024-10-10 DOI:10.3390/biom14101276

Jolien Zwama, Neeltje M Rosenberg, Vincent A Verheij, Pieter G H M Raijmakers, Maqsood Yaqub, Esmée Botman, Ruben D de Ruiter, Mark R Garrelfs, Arend Bökenkamp, Dimitra Micha, Lothar A Schwarte, Bernd P Teunissen, Adriaan A Lammertsma, Ronald Boellaard, Elisabeth M W Eekhoff

{"title":"[18F]NaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders.","authors":"Jolien Zwama, Neeltje M Rosenberg, Vincent A Verheij, Pieter G H M Raijmakers, Maqsood Yaqub, Esmée Botman, Ruben D de Ruiter, Mark R Garrelfs, Arend Bökenkamp, Dimitra Micha, Lothar A Schwarte, Bernd P Teunissen, Adriaan A Lammertsma, Ronald Boellaard, Elisabeth M W Eekhoff","doi":"10.3390/biom14101276","DOIUrl":null,"url":null,"abstract":"Fibrodysplasia ossificans progressiva (FOP) is a rare genetic bone disorder characterized by episodic flare-ups in connective tissue, which are frequently followed by the formation of heterotopic ossification. The absence of available plasma-soluble biomarkers for flare-ups or heterotopic bone formation poses severe challenges to the monitoring of disease activity to measure or predict disease progression. Recently, 18-fluor-sodium fluoride positron emission tomography/computed tomography ([18F]NaF PET/CT) was introduced as a potential marker for ossifying FOP activity. This review discusses the pharmacokinetics of [18F]NaF in relation to the pathophysiology of FOP, and its use as a marker of local bone metabolism in a variety of bone-related disorders. In addition, the review specifically addresses the applicability of [18F]NaF PET/CT imaging in FOP as a monitoring modality.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505869/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomolecules","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3390/biom14101276","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic bone disorder characterized by episodic flare-ups in connective tissue, which are frequently followed by the formation of heterotopic ossification. The absence of available plasma-soluble biomarkers for flare-ups or heterotopic bone formation poses severe challenges to the monitoring of disease activity to measure or predict disease progression. Recently, 18-fluor-sodium fluoride positron emission tomography/computed tomography ([¹⁸F]NaF PET/CT) was introduced as a potential marker for ossifying FOP activity. This review discusses the pharmacokinetics of [¹⁸F]NaF in relation to the pathophysiology of FOP, and its use as a marker of local bone metabolism in a variety of bone-related disorders. In addition, the review specifically addresses the applicability of [¹⁸F]NaF PET/CT imaging in FOP as a monitoring modality.

查看原文本刊更多论文

将[18F]NaF PET/CT 作为渐进性骨纤维增生症的标记物：从骨疾病的分子机制到临床应用。

进行性骨化性纤维增生症（FOP）是一种罕见的遗传性骨病，其特征是结缔组织的阵发性发作，发作后经常形成异位骨化。由于缺乏可用于检测疾病发作或异位骨形成的血浆可溶性生物标记物，这给监测疾病活动以衡量或预测疾病进展带来了严峻挑战。最近，18-氟化钠正电子发射断层扫描/计算机断层扫描（[18F]NaF PET/CT）作为骨化性 FOP 活动的潜在标志物被引入临床。本综述讨论了[18F]NaF 的药代动力学与 FOP 病理生理学的关系，以及它在各种骨相关疾病中作为局部骨代谢标志物的用途。此外，该综述还特别讨论了[18F]NaF PET/CT 成像作为一种监测方式在 FOP 中的适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.