The dynamic crosslinking between gut microbiota and inflammation during aging: reviewing the nutritional and hormetic approaches against dysbiosis and inflammaging.

IF 4.4 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2024-10-23 DOI:10.1007/s10522-024-10146-2

Sakshi Chaudhary, Pardeep Kaur, Thokchom Arjun Singh, Kaniz Shahar Bano, Ashish Vyas, Alok Kumar Mishra, Prabhakar Singh, Mohammad Murtaza Mehdi

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引用次数: 0

Abstract

The early-life gut microbiota (GM) is increasingly recognized for its contributions to human health and disease over time. Microbiota composition, influenced by factors like race, geography, lifestyle, and individual differences, is subject to change. The GM serves dual roles, defending against pathogens and shaping the host immune system. Disruptions in microbial composition can lead to immune dysregulation, impacting defense mechanisms. Additionally, GM aids digestion, releasing nutrients and influencing physiological systems like the liver, brain, and endocrine system through microbial metabolites. Dysbiosis disrupts intestinal homeostasis, contributing to age-related diseases. Recent studies are elucidating the bacterial species that characterize a healthy microbiota, defining what constitutes a 'healthy' colonic microbiota. The present review article focuses on the importance of microbiome composition for the development of homeostasis and the roles of GM during aging and the age-related diseases caused by the alteration in gut microbial communities. This article might also help the readers to find treatments targeting GM for the prevention of various diseases linked to it effectively.

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衰老过程中肠道微生物群与炎症之间的动态交叉联系：回顾对抗菌群失调和炎症的营养和激素方法。

随着时间的推移，人们越来越认识到生命早期肠道微生物群（GM）对人类健康和疾病的贡献。微生物群的组成受种族、地理、生活方式和个体差异等因素的影响，会发生变化。微生物群具有双重作用，既能抵御病原体，又能塑造宿主免疫系统。微生物组成紊乱会导致免疫失调，影响防御机制。此外，转基因还能帮助消化，释放营养物质，并通过微生物代谢产物影响肝脏、大脑和内分泌系统等生理系统。菌群失调会破坏肠道平衡，导致与年龄有关的疾病。最近的研究正在阐明健康微生物群的细菌种类，从而确定什么是 "健康 "的结肠微生物群。本综述文章重点探讨了微生物群组成对平衡发展的重要性、转基因在衰老过程中的作用以及肠道微生物群落改变导致的老年相关疾病。本文还可能帮助读者找到针对转基因的治疗方法，以有效预防与之相关的各种疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.