ARISE-The Accuracy Evaluation of a Patient-Specific 3D-Printed Biopsy System Based on MRI Data: A Cadaveric Study.

IF 3.8 3区医学 Q2 ENGINEERING, BIOMEDICAL

Bioengineering Pub Date : 2024-10-11 DOI:10.3390/bioengineering11101013

Robert Möbius, Dirk Winkler, Fabian Kropla, Marcel Müller, Sebastian Scholz, Erdem Güresir, Ronny Grunert

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引用次数: 0

Abstract

Background: Brain biopsy is required for the accurate specification and further diagnosis of intracranial findings. The conventional stereotactic frames are used clinically for biopsies and offer the highest possible precision. Unfortunately, they come with some insurmountable technical and logistical limitations. The aim of the present work is to determine the clinical precision in the needle biopsy of the human brain using a new patient-specific stereotactic navigation device based on 3D printing.

Methods: MRI data sets of human cadaver heads were used to plan 32 intracranial virtual biopsy targets located in different brain regions. Based on these data, 16 individualized stereotactic frames were 3D-printed. After the intraoperative application of the stereotactic device to the cadaver's head, the actual needle position was verified by postoperative CT.

Results: Thirty-two brain areas were successfully biopsied. The target point accuracy was 1.05 ± 0.63 mm, which represents the difference between the planned and real target points. The largest target point deviation was in the coronal plane at 0.60 mm; the smallest was in the transverse plane (0.45 mm).

Conclusions: Three-dimensional-printed, personalized stereotactic frames or platforms are an alternative to the commonly used frame-based and frameless stereotactic systems. They are particularly advantageous in terms of accuracy, reduced medical imaging, and significantly simplified intraoperative handling.

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ARISE--基于核磁共振成像数据的患者特异性三维打印活检系统的准确性评估：尸体研究。

背景：要对颅内病变进行准确的分类和进一步诊断，就必须进行脑活检。传统的立体定向框架用于临床活检，具有最高的精确度。遗憾的是，它们存在一些难以克服的技术和后勤限制。本研究的目的是利用基于 3D 打印技术的新型患者特异性立体定向导航设备，确定人脑穿刺活检的临床精确度：方法：使用人体尸体头部的磁共振成像数据集来规划位于不同脑区的 32 个颅内虚拟活检目标。根据这些数据，3D打印出16个个性化立体定向框架。术中将立体定向装置应用于尸体头部后，通过术后 CT 验证了针头的实际位置：结果：成功活检了 32 个脑区。靶点精确度为 1.05 ± 0.63 毫米，即计划靶点与实际靶点之间的差值。最大的靶点偏差出现在冠状面，为 0.60 毫米；最小的偏差出现在横向面，为 0.45 毫米：结论：三维打印的个性化立体定向框架或平台是常用的有框架和无框架立体定向系统的替代品。结论：三维打印个性化立体定向框架或平台可替代常用的有框和无框立体定向系统，在精确度、减少医学影像和显著简化术中操作方面尤其具有优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioengineering Chemical Engineering-Bioengineering

CiteScore

4.00

自引率

8.70%

发文量

661

期刊介绍： Aims Bioengineering (ISSN 2306-5354) provides an advanced forum for the science and technology of bioengineering. It publishes original research papers, comprehensive reviews, communications and case reports. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. All aspects of bioengineering are welcomed from theoretical concepts to education and applications. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, four key features of this Journal: ● We are introducing a new concept in scientific and technical publications “The Translational Case Report in Bioengineering”. It is a descriptive explanatory analysis of a transformative or translational event. Understanding that the goal of bioengineering scholarship is to advance towards a transformative or clinical solution to an identified transformative/clinical need, the translational case report is used to explore causation in order to find underlying principles that may guide other similar transformative/translational undertakings. ● Manuscripts regarding research proposals and research ideas will be particularly welcomed. ● Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. ● We also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds. Scope ● Bionics and biological cybernetics: implantology; bio–abio interfaces ● Bioelectronics: wearable electronics; implantable electronics; “more than Moore” electronics; bioelectronics devices ● Bioprocess and biosystems engineering and applications: bioprocess design; biocatalysis; bioseparation and bioreactors; bioinformatics; bioenergy; etc. ● Biomolecular, cellular and tissue engineering and applications: tissue engineering; chromosome engineering; embryo engineering; cellular, molecular and synthetic biology; metabolic engineering; bio-nanotechnology; micro/nano technologies; genetic engineering; transgenic technology ● Biomedical engineering and applications: biomechatronics; biomedical electronics; biomechanics; biomaterials; biomimetics; biomedical diagnostics; biomedical therapy; biomedical devices; sensors and circuits; biomedical imaging and medical information systems; implants and regenerative medicine; neurotechnology; clinical engineering; rehabilitation engineering ● Biochemical engineering and applications: metabolic pathway engineering; modeling and simulation ● Translational bioengineering