Bacteriophage entrapment strategies for the treatment of chronic wound infections: a comprehensive review

IF 2.3 3区 生物学 Q3 MICROBIOLOGY
Nivedya Mohan, Kiran Bosco, Anmiya Peter, K. Abhitha, Sarita G. Bhat
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引用次数: 0

Abstract

The growing threat of antimicrobial resistance has made the quest for antibiotic alternatives or synergists one of the most pressing priorities of the 21st century. The emergence of multidrug-resistance in most of the common wound pathogens has amplified the risk of antibiotic-resistant wound infections. Bacteriophages, with their self-replicating ability and targeted specificity, can act as suitable antibiotic alternatives. Nevertheless, targeted delivery of phages to infection sites remains a crucial issue, specifically in the case of topical infections. Hence, different phage delivery systems have been studied in recent years. However, there have been no recent reviews of phage delivery systems focusing exclusively on phage application on wounds. This review provides a compendium of all the major delivery systems that have been used to deliver phages to wound infection sites. Special focus has also been awarded to phage-embedded hydrogels with a discussion on the different aspects to be considered during their preparation.

Graphical abstract

治疗慢性伤口感染的噬菌体诱捕策略:全面综述。
抗生素耐药性的威胁与日俱增,寻找抗生素替代品或增效剂已成为 21 世纪最紧迫的优先事项之一。大多数常见伤口病原体对多种药物产生耐药性,这增加了伤口感染产生抗生素耐药性的风险。噬菌体具有自我复制能力和靶向特异性,可以作为合适的抗生素替代品。然而,将噬菌体定向输送到感染部位仍然是一个关键问题,特别是在局部感染的情况下。因此,近年来对不同的噬菌体递送系统进行了研究。然而,最近还没有专门针对噬菌体在伤口上应用的噬菌体递送系统的综述。本综述汇编了所有用于将噬菌体输送到伤口感染部位的主要输送系统。本综述还特别关注了噬菌体包埋水凝胶,并讨论了在制备过程中需要考虑的不同方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Archives of Microbiology
Archives of Microbiology 生物-微生物学
CiteScore
4.90
自引率
3.60%
发文量
601
审稿时长
3 months
期刊介绍: Research papers must make a significant and original contribution to microbiology and be of interest to a broad readership. The results of any experimental approach that meets these objectives are welcome, particularly biochemical, molecular genetic, physiological, and/or physical investigations into microbial cells and their interactions with their environments, including their eukaryotic hosts. Mini-reviews in areas of special topical interest and papers on medical microbiology, ecology and systematics, including description of novel taxa, are also published. Theoretical papers and those that report on the analysis or ''mining'' of data are acceptable in principle if new information, interpretations, or hypotheses emerge.
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