Clinical features and effects of cyclosporine in the treatment of psoriasis: a systemic review and meta-analysis

IF 1.8 4区医学 Q3 DERMATOLOGY

Archives of Dermatological Research Pub Date : 2024-10-26 DOI:10.1007/s00403-024-03425-y

Zaibing Li, Baoqiang Pei, Tianbing Lei, Ming Yao, Yanchao Niu, Peimei Zhou, Yonghong Lu, Yan Tang

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引用次数: 0

Abstract

To systematically evaluate clinical features and effects of cyclosporine in the treatment of psoriasis. Databases including Web of Science, PubMed, The Cochrane Library, Embase, CNKI, Wan Fang, and VIP were electronically searched for studies on the use of cyclosporine in the treatment of psoriasis, from inception to March 2024. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias of the included studies. A meta-analysis was then performed. A total of 12 randomised controlled trial (RCT) studies were included. Compared with the control group, there were statistically significant differences in the effective rate, recurrence rate, erythema regression time, pustular resolution time, fever resolution time, and Psoriasis Area Severity Index (PASI) score of cyclosporine in the treatment of psoriasis. Moreover, the sub-group analysis showed that the effective rate of patients aged less than 40 years was significantly higher than that of the control group and the recurrence rate was significantly lower than that of the control group. The effective rate of psoriasis patients without nail lesions was significantly higher than that of control group. The effective rate of cyclosporin was significantly higher than that of dexamethasone acetate. There was no significant change in pooled sensitivity and specificity after each study was excluded one by one, indicating the stability of the meta-analysis. Cyclosporine had a high effective rate and low recurrence rate in the treatment of psoriasis, but it still had similar rate of adverse reactions compared to other drugs. This study systematically evaluated the effect of cyclosporine in the treatment of psoriasis and provided reference for clinical practice.

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环孢素治疗银屑病的临床特点和效果：系统回顾和荟萃分析。

系统评估环孢素治疗银屑病的临床特点和效果。通过电子方式在 Web of Science、PubMed、The Cochrane Library、Embase、CNKI、万方和 VIP 等数据库中检索了从开始到 2024 年 3 月期间有关使用环孢素治疗银屑病的研究。两位审稿人独立筛选文献、提取数据并评估了纳入研究的偏倚风险。然后进行了荟萃分析。共纳入了 12 项随机对照试验 (RCT) 研究。与对照组相比，环孢素治疗银屑病的有效率、复发率、红斑消退时间、脓疱消退时间、发热消退时间和银屑病面积严重程度指数（PASI）评分均有显著统计学差异。此外，亚组分析显示，40 岁以下患者的有效率明显高于对照组，复发率明显低于对照组。无指甲病变的银屑病患者的有效率明显高于对照组。环孢素的有效率明显高于醋酸地塞米松。在逐一剔除每项研究后，汇总的敏感性和特异性均无明显变化，这表明荟萃分析具有稳定性。环孢素治疗银屑病的有效率高、复发率低，但与其他药物相比，其不良反应发生率仍然相似。本研究系统评价了环孢素治疗银屑病的效果，为临床实践提供了参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Dermatological Research 医学-皮肤病学

CiteScore

4.10

自引率

3.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.