What is the effect of lithium use on the amygdalar volume of adult patients diagnosed with bipolar disorder: a scoping review.

IF 3.6 3区 医学 Q1 PSYCHIATRY
Anshika Solleti, Aleena Naeem
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引用次数: 0

Abstract

Introduction: Bipolar disorder is a psychiatric condition commonly treated with lithium. This treatment has various biological effects on the brain; however, variability in the areas and types of changes as a result of lithium treatment has resulted in discourse over lithium's effect. As a result, a comprehensive synthesis is needed to understand lithium's true neurological effect. This review aims to identify a common result of lithium use in the neurobiology of bipolar patients, specifically in the amygdala, to determine whether volumetric changes in the amygdala are a common effect.

Methods: We conducted a preliminary search to identify key search terms across electronic databases, including Google Scholar and PubMed. After screening and application of inclusion and exclusion criteria, 9 cross-sectional studies were identified.

Results: The evidence from these cross-sectional studies showed either an increase or no change in amygdalar volume. While this fails to identify a definite pattern in amygdalar volume changes, it highlights a need for further research to identify sources of heterogeneity and minimize them to ascertain accurate results.

Conclusions: The present review may be used to influence future work concerning neurobiological changes in the amygdala as a result of lithium treatment for bipolar patients by summarizing patterns in the current literature.

使用锂对被诊断为双相情感障碍的成年患者的杏仁体积有何影响:范围综述。
简介躁郁症是一种精神疾病,通常用锂来治疗。这种治疗方法会对大脑产生各种生物效应;然而,由于锂治疗所导致的变化的领域和类型各不相同,导致人们对锂的效应议论纷纷。因此,需要进行全面的综述,以了解锂对神经系统的真正影响。本综述旨在找出锂对躁郁症患者神经生物学的共同影响,特别是杏仁核,以确定杏仁核的体积变化是否是一种共同影响:我们进行了初步检索,以确定包括谷歌学术和 PubMed 在内的电子数据库中的关键检索词。经过筛选并应用纳入和排除标准后,确定了 9 项横断面研究:结果:这些横断面研究的证据显示,杏仁核体积要么有所增加,要么没有变化。虽然这并不能确定杏仁核体积变化的明确模式,但它强调了进一步研究的必要性,以确定异质性的来源并将其最小化,从而确定准确的结果:本综述通过总结现有文献中的模式,可用于影响未来有关锂治疗双相情感障碍患者后杏仁核神经生物学变化的研究工作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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