An innovative strategy for Gefitinib quantification in pharmaceutical and plasma samples using a graphene quantum dots-combined gold nanoparticles composite electrochemical sensor

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2024-10-24 DOI:10.1007/s00604-024-06766-7

Jieping Cao, Yingmei Shi, Juntong Chen, Zhibin Yan, Minmin Zhang, Mingliang Jin, Lingling Shui, Zhenping Liu, Huiling Feng

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Abstract

An innovative methodology is proposed for quantifying Gefitinib (GFT) using an electrochemical sensor constructed from a composite of graphene quantum dots (GQDs) and gold nanoparticles (AuNPs). GQDs were synthesized from graphite, preserving graphene’s large surface area and excellent electron transfer capabilities while enhancing dispersibility. The combination of GQDs with AuNPs resulted in an AuNPs@GQDs composite, which was used to construct the sensor. The synthesized nanomaterials were characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and the electrochemical performance of the sensor was evaluated via cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Under optimized conditions, the sensor displayed a linear calibration curve for GFT detection within the range 0.01 to 10.0 µM, with a limit of detection (LOD) of 0.005 µM (S/N = 3). The sensor demonstrated excellent anti-interference properties and stability in tests using pharmaceutical formulations and plasma samples. Compared to chromatographic methods, the sensor exhibited similar accuracy and recovery. Its easy fabrication and high sensitivity make it a promising tool for pharmaceutical analysis and clinical therapeutic drug monitoring.

Graphical Abstract

查看原文本刊更多论文

利用石墨烯量子点-金纳米颗粒复合电化学传感器定量检测药物和血浆样品中吉非替尼的创新策略。

本文提出了一种利用石墨烯量子点（GQDs）和金纳米粒子（AuNPs）复合材料构建的电化学传感器定量检测吉非替尼（GFT）的创新方法。GQDs 由石墨合成，保留了石墨烯的大表面积和出色的电子传递能力，同时提高了分散性。将 GQDs 与 AuNPs 结合后得到 AuNPs@GQDs 复合材料，用于构建传感器。利用扫描电子显微镜（SEM）和透射电子显微镜（TEM）对合成的纳米材料进行了表征，并通过循环伏安法（CV）和差分脉冲伏安法（DPV）对传感器的电化学性能进行了评估。在优化条件下，传感器在 0.01 至 10.0 µM 范围内显示出线性 GFT 检测校准曲线，检测限为 0.005 µM（信噪比为 3）。在使用药物制剂和血浆样品进行的测试中，该传感器表现出卓越的抗干扰性能和稳定性。与色谱法相比，该传感器具有相似的准确度和回收率。该传感器易于制造，灵敏度高，是药物分析和临床治疗药物监测的理想工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.