The Protective Role of Baicalin in the Regulation of NLRP3 Inflammasome in Different Diseases.

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Biophysics Pub Date : 2024-10-23 DOI:10.1007/s12013-024-01597-y

Qi Zhang, Shiyun Guo, Honggang Wang

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引用次数: 0

Abstract

The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome consists of pro-caspase-1, NLRP3 and apoptosis-related speckle-like protein (ASC). It can detect multiple microorganisms, endogenous danger signals and environmental stimulus including adenosine triphosphate (ATP), urate, cholesterol crystals, and so on, thereby forming activated NLRP3 inflammasome. During the course of the activation of NLRP3 inflammasome, pro-caspase-1 is transformed into activated caspase-1 that results in the maturation and secretion of interleukin-1beta (IL-1β) and IL-18. The dysfunction of NLRP3 inflammasome participates in multiple diseases such as liver diseases, renal diseases, nervous system diseases and diabetes. Baicalin is the primary bioactive component of Scutellaria baicalensis, which has been used since ancient times. Baicalin has many types of biological functions, such as anti-bacterial, anti-tumor and antioxidant. More and more evidence suggests that baicalin regulation of NLRP3 inflammasome is involved in different diseases. However, the mechanism is still elusive. Here, we reviewed the progress of baicalin regulation of NLRP3 inflammasome in many kinds of diseases to lay a foundation for future researches.

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黄芩苷在不同疾病中调控 NLRP3 炎症小体的保护作用

含NACHT、LRR和PYD结构域的蛋白3（NLRP3）炎性小体由原aspase-1、NLRP3和凋亡相关斑点样蛋白（ASC）组成。它能检测多种微生物、内源性危险信号和环境刺激，包括三磷酸腺苷（ATP）、尿酸盐、胆固醇结晶等，从而形成活化的 NLRP3 炎症小体。在激活 NLRP3 炎症小体的过程中，pro-caspase-1 转变为活化的 caspase-1，导致白细胞介素-1β（IL-1β）和 IL-18 的成熟和分泌。NLRP3 炎性体的功能障碍参与多种疾病的发生，如肝脏疾病、肾脏疾病、神经系统疾病和糖尿病。黄芩苷是黄芩的主要生物活性成分，自古以来一直被人们使用。黄芩苷具有多种生物功能，如抗菌、抗肿瘤和抗氧化等。越来越多的证据表明，黄芩苷对 NLRP3 炎症小体的调控与不同疾病有关。然而，其中的机理仍然难以捉摸。在此，我们回顾了黄芩苷在多种疾病中调控NLRP3炎性体的研究进展，为今后的研究奠定基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

7.5 months

期刊介绍： Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.