Validation of a smartphone-compatible MIP-based sensor for bisphenol A determination in wastewater samples.

IF 3.8 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Analytical and Bioanalytical Chemistry Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI:10.1007/s00216-024-05616-y

Daria Yarynka, Anton Honcharenko, Larysa Gorbach, Elena Piletska, Sergey Piletsky, Oleksandr Brovko, Tetyana Sergeyeva

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Abstract

A handheld smartphone-compatible molecularly imprinted polymer (MIP)-based sensor was developed for the analysis of bisphenol A (BPA) in wastewater samples. Sensing elements based on ethylene glycol methacrylate phosphate (EGMP)-containing MIP films were designed and optimized using molecular dynamics simulations. The highly porous MIP films were synthesized via in situ polymerization, employing a fragment-based approach. The colorimetric response was based on the 4-aminoantipyrine method, while the MIP films were further utilized to detect BPA with a smartphone. The proposed sensor exhibited a wide linear range from 5 to 250 μM, with a limit of detection (LOD) of 5 μM (S/N = 3). Furthermore, the designed analytical system demonstrated excellent analytical performance in terms of selectivity, stability, and reproducibility. During sensor validation, real wastewater samples were successfully tested for BPA, showcasing the feasibility of the smartphone-compatible MIP-based sensor. Recovery values of 87.1-114.6% underscored the efficacy and reliability of the developed sensor system.

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验证兼容智能手机的基于 MIP 的传感器在废水样本中测定双酚 A。

为分析废水样品中的双酚 A (BPA)，开发了一种与智能手机兼容的基于分子印迹聚合物 (MIP) 的手持式传感器。利用分子动力学模拟设计并优化了基于含甲基丙烯酸乙二醇酯磷酸酯（EGMP）MIP 薄膜的传感元件。采用基于片段的方法，通过原位聚合合成了高多孔性 MIP 薄膜。比色反应基于 4-氨基安替比林法，而 MIP 薄膜则被进一步用于用智能手机检测双酚 A。该传感器的线性范围很宽，从 5 μM 到 250 μM，检测限（LOD）为 5 μM（信噪比为 3）。此外，所设计的分析系统在选择性、稳定性和再现性方面都表现出了卓越的分析性能。在传感器验证过程中，成功检测了真实废水样品中的双酚 A，展示了基于 MIP 的智能手机兼容传感器的可行性。87.1-114.6% 的回收率突出了所开发传感器系统的有效性和可靠性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytical and Bioanalytical Chemistry 化学-分析化学

CiteScore

8.00

自引率

4.70%

发文量

638

审稿时长

2.1 months

期刊介绍： Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.