An injectable thermosensitive pluronic F127 loaded-nanohydroxyapatite / Polydopamine for promoting sciatic nerve repair after crush injury.

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-10-16 DOI:10.1016/j.colsurfb.2024.114324

Liyuan Kang, Enlai Fang, Muge Gu, Yuanye Guan, Di Wu, Xiangqi Zhang, Wei Yu, Jiayu Wang, Zhen Zeng, Shengjing Xu, Yanjie He, Wei-En Yuan

引用次数: 0

Abstract

Peripheral nerve injury (PNI) remains an urgent issue due to its huge financial burden and high rate of disability. Here, an injectable HAP/PDA thermosensitive pluronic F-127 (PF-127) hydrogel is proposed for peripheral nerve repair. We investigated the surface characteristics of HAP/PDA and evaluated biocompatibility, cellular proliferation, differentiation, and apoptosis in vitro. After injecting the hydrogel into the injured site of rats, we recorded the recovery of motor function and judged the degree of nerves through electrophysiological and morphological changes. The hydrogel was found to accelerate the nerve regeneration. Collectively, the HAP/PDA thermosensitive PF-127 hydrogel has potential in promoting sciatic nerve repair.

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一种可注射的热敏性 pluronic F127 负载纳米羟基磷灰石/聚多巴胺，用于促进挤压伤后的坐骨神经修复。

周围神经损伤（PNI）因其巨大的经济负担和高致残率而一直是一个亟待解决的问题。本文提出了一种可注射的 HAP/PDA 热敏性 pluronic F-127 (PF-127) 水凝胶，用于周围神经修复。我们研究了 HAP/PDA 的表面特性，并在体外评估了其生物相容性、细胞增殖、分化和凋亡情况。将水凝胶注入大鼠受伤部位后，我们记录了运动功能的恢复情况，并通过电生理学和形态学变化判断神经的程度。结果发现，水凝胶能加速神经再生。综上所述，HAP/PDA 热敏 PF-127 水凝胶具有促进坐骨神经修复的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.