Clinical and Genomic Epidemiology of Coxsackievirus A21 and Enterovirus D68 in Homeless Shelters, King County, Washington, USA, 2019-2021.

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2024-11-01 DOI:10.3201/eid3011.240687

Sarah N Cox,Amanda M Casto,Nicholas M Franko,Eric J Chow,Peter D Han,Luis Gamboa,Brian Pfau,Hong Xie,Kevin Kong,Jaydee Sereewit,Melissa A Rolfes,Emily Mosites,Timothy M Uyeki,Alexander L Greninger,Marco Carone,M Mia Shim,Trevor Bedford,Jay Shendure,Michael Boeckh,Janet A Englund,Lea M Starita,Pavitra Roychoudhury,Helen Y Chu

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引用次数: 0

Abstract

Congregate homeless shelters are disproportionately affected by infectious disease outbreaks. We describe enterovirus epidemiology across 23 adult and family shelters in King County, Washington, USA, during October 2019-May 2021, by using repeated cross-sectional respiratory illness and environmental surveillance and viral genome sequencing. Among 3,281 participants >3 months of age, we identified coxsackievirus A21 (CVA21) in 39 adult residents (3.0% [95% CI 1.9%-4.8%] detection) across 7 shelters during October 2019-February 2020. We identified enterovirus D68 (EV-D68) in 5 adult residents in 2 shelters during October-November 2019. Of 812 environmental samples, 1 was EV-D68-positive and 5 were CVA21-positive. Other enteroviruses detected among residents, but not in environmental samples, included coxsackievirus A6/A4 in 3 children. No enteroviruses were detected during April 2020-May 2021. Phylogenetically clustered CVA21 and EV-D68 cases occurred in some shelters. Some shelters also hosted multiple CVA21 lineages.

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美国华盛顿州金县无家可归者收容所柯萨奇病毒 A21 和肠道病毒 D68 的临床和基因组流行病学，2019-2021 年。

无家可归者集中收容所受到传染病爆发的影响尤为严重。2019年10月至2021年5月期间，我们通过重复横断面呼吸道疾病和环境监测以及病毒基因组测序，描述了美国华盛顿州金县23个成人和家庭收容所的肠道病毒流行病学。在 3,281 名年龄大于 3 个月的参与者中，我们在 2019 年 10 月至 2020 年 2 月期间在 7 个避难所的 39 名成年居民中发现了柯萨奇病毒 A21（CVA21）（检出率为 3.0% [95% CI 1.9%-4.8%]）。2019 年 10 月至 11 月期间，我们在 2 个避难所的 5 名成年居民中发现了肠道病毒 D68 (EV-D68)。在 812 份环境样本中，1 份为 EV-D68 阳性，5 份为 CVA21 阳性。在居民中检测到但未在环境样本中检测到的其他肠道病毒包括在 3 名儿童中检测到的柯萨奇病毒 A6/A4。2020 年 4 月至 2021 年 5 月期间未检测到肠道病毒。一些避难所出现了 CVA21 和 EV-D68 系统发育聚集病例。一些避难所还存在多个 CVA21 系。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.