Industrial-Scale Organic Solvent Nanofiltration for Dimer Impurity Removal: Enhancing Vitamin D3 Production

IF 3.1 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2024-10-25 DOI:10.1021/acs.oprd.4c00333

Jan Schütz, Julia Witte, Maurus Marty, Roman Goy

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Abstract

This work details the removal of an azine-dimer (AD) impurity from 7-dehydrocholesterol (DHC), a precursor of vitamin D₃, using a newly developed, sustainable hybrid membrane process, from the idea to implementation. Developed by an international team collaborating under tight time frame and COVID restrictions, this innovative method exemplifies a versatile, energy-saving, and cost-effective separation technology by organic solvent nanofiltration (OSN). Traditional purification methods proved to be unsuccessful, costly, or unsustainable, but this process achieved DHC purification with a minimal yield loss of 0.1%. This separation challenge goes beyond typical OSN applications (solute concentration or solvent exchange) by separating two similar solutes in a solvent mixture. In a three-stage OSN process, the impurity level was reduced from approximately 2600 ppm to below 50 ppm in the final permeate. After developing and scaling up the process, the OSN, precipitation, and filtration units were engineered and constructed. These units were installed in the dsm-firmenich vitamin D₃ plant, and the purification process was successfully commissioned.

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用于去除二聚体杂质的工业级有机溶剂纳滤：提高维生素 D3 的产量

这项工作详细介绍了利用新开发的可持续混合膜工艺，从构思到实施，从维生素 D3 的前体 7-脱氢胆固醇（DHC）中去除偶氮二聚体（AD）杂质的过程。该创新方法是由一个国际团队在紧迫的时间框架和 COVID 限制下合作开发的，是有机溶剂纳滤（OSN）分离技术中多功能、节能和经济高效的典范。传统的纯化方法被证明是不成功的、昂贵的或不可持续的，但这一工艺实现了 DHC 的纯化，而且产量损失极小，仅为 0.1%。这一分离挑战超越了典型的 OSN 应用（溶质浓缩或溶剂交换），在溶剂混合物中分离两种相似的溶质。在三级 OSN 工艺中，最终渗透物中的杂质含量从约 2600 ppm 降至 50 ppm 以下。在开发和扩大工艺规模之后，OSN、沉淀和过滤装置被设计和建造出来。这些装置已安装在 dsm-firmenich 维生素 D3 工厂，提纯工艺已成功投入使用。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.